Incidence and clinical impact of thrombus after stent implantation in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study
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Department of Cardiology, Hirosaki University Graduate School of Medicine
抄録
Background: We previously reported that ST-segment elevation myocardial nfarction（ STEMI） patients with large residual thrombus burden after thrombectomy before stent implantation had more severe microvascular dysfunction, and greater yocardial damage compared with those with small residual thrombus. However, linical significance of residual thrombus after stent implantation in STEMI atients is unclear.
Aims: This study aimed to evaluate the incidence of thrombus by optical coherence tomography （OCT） after stent implantation, and to investigate its clinical mpact in STEMI patients.
Methods and Results: A total of 180 STEMI patients within 12 hours after onset of symptoms were studied. Patients were divided into two groups according to OCT indings after stent implantation: thrombus group（ n = 73） and nonthrombus group（ n = 107）. Peak CPK levels were greater in thrombus group than in non-thrombus group with close to significance （3649 {1752-7053｝ versus. 2563 {1201-4282｝IU/L, p = 0.053）. Thrombus after stent implantation was independently associated with peak CPK levels by a stepwise multivariate analysis.
Conclusions: Residual thrombus on OCT after stent implantation was detected in 1% of STEMI patients. The residual thrombus was associated with greater myocardial damage assessed by peak CPK levels, indicating clinical impact of OCT-detected thrombus in STEMI patients.
運用指針・許諾書
Incidence and clinical impact of thrombus after stent implantation in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study
Hirosaki Med J 70-2-4_139
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