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Combined Treatment Effects of Irradiation and SN-38, an Active Metabolite of Camptothecin Derivative Irinotecan, on the Human Tumor Cell Line PECA 4197
http://hdl.handle.net/10129/5040
http://hdl.handle.net/10129/50408dcbc9de-0277-4cb7-abee-8180fd340698
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_51_10.pdf (505.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-10-18 | |||||
タイトル | ||||||
タイトル | Combined Treatment Effects of Irradiation and SN-38, an Active Metabolite of Camptothecin Derivative Irinotecan, on the Human Tumor Cell Line PECA 4197 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SN-38 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | irinotecan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | irradiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inhibitionofPLDR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Clonogenicsurvivalassay | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | イリノテカン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 放射線照射 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 潜在的致死損傷からの回復阻害 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | コロニー法 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mariya, Yasushi
× Mariya, Yasushi× Streffer, Christian× Zolzer, Friedo× Abe, Yoshinao |
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著者(ヨミ) | ||||||
姓名 | マリヤ, ヤスシ | |||||
著者(ヨミ) | ||||||
姓名 | アベ, ヨシナオ | |||||
著者別名 | ||||||
姓名 | 真里谷, 靖 | |||||
著者別名 | ||||||
姓名 | 阿部, 由直 | |||||
著者所属 | ||||||
Department of Radiology,Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Institut ftir Medizinische Strahlenbiologie,Universitats-klinikum Essen | ||||||
著者所属 | ||||||
弘前大学医学部放射線医学講座 | ||||||
著者所属 | ||||||
ドイツ・エッセン大学医学放射線生物学研究所 | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The in vitro combined effects of irradiation and SN-38, an active metabolite of irinotecan, on the human squamous cell carcinoma cell line PECA4197 derived from a head and neck carcinoma were examined.Exponentially growing cell cultures were pretreated with SN-38 for 90 min, in the concentration of 0.005 and 0.5μg/ml, respectively,and then irradiated. As a control, cells without pretreatment were also irradiated. The cell survival rate was determined using a conventional clonogenic survival assay. The enhanced effects of radiation-induced cell killing, depending upon the concentration of SN-38, were presented with a decrease of shoulder part or extrapolation number (n) of survival curve, corrected for the cytotoxicity of SN-38 alone. The value of D0 was unchanged after SN-38 pretreatment. These results suggested that the pretreatment with SN-38 inhibited potentially lethal damage repair in the cell line, leading to the potentiation of irradiation effects. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 51(1), 1999, p.10-14 | |||||
書誌情報 |
弘前医学 巻 51, 号 1, p. 10-14, 発行日 1999-08-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 494.54 | |||||
その他のタイトル | ||||||
その他のタイトル | ヒト腫瘍培養細胞株PECA4197に対する放射線およびSN-38(カンプトテシン誘導体イリノテカン活性代謝物)併用効果 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | ヒト シュヨウ バイヨウ サイボウカブ PECA4197 ニ タイスル ホウシャセン オヨビ SN-38 カンプトテシン ユウドウタイ イリノテカン カッセイ タイシャブツ ヘイヨウ コウカ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 外科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学医学部・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |