WEKO3
アイテム
{"_buckets": {"deposit": "d619359b-7ffe-44ed-ac8c-88544d1dac6e"}, "_deposit": {"created_by": 3, "id": "3583", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "3583"}, "status": "published"}, "_oai": {"id": "oai:hirosaki.repo.nii.ac.jp:00003583", "sets": ["637"]}, "author_link": ["11272", "11280", "11078", "11074", "11279", "11278", "11270", "11275", "11274", "11271", "11082", "11276"], "item_5_alternative_title_21": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "直接シークエンス法による大腸癌手術症例におけるp53遺伝子変異の予後の検討"}]}, "item_5_alternative_title_22": {"attribute_name": "タイトル(ヨミ)", "attribute_value_mlt": [{"subitem_alternative_title": "チョクセツ シークエンスホウ ニヨル ダイチョウガン シュジュツ ショウレイ ニオケル p53 イデンシ ヘンイ ノ ヨゴ ノ ケントウ"}]}, "item_5_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-03-31", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2/3/4", "bibliographicPageEnd": "78", "bibliographicPageStart": "69", "bibliographicVolumeNumber": "56", "bibliographic_titles": [{"bibliographic_title": "弘前医学"}]}]}, "item_5_description_17": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_5_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To evaluate the clinical significance of p53 mutations, we analyzed the relationship of several clinicopathologic factors to the clinical outcomes in 131 colorectal cancer patients. Exons 5 to 9 of the p53 gene were studied by the direct sequencing method with capillary electrophoresis. A total of 47 mutations of p53 were found, in 45 of 131 cases (34%). Mutations were statistically associated with lymphatic invasion (p=0.03) and lymph node metastasis (p=0.02). Kaplan-Meier survival curves for the patients with p53 mutations were likely to exhibit shortened survivals, but the difference was not statistically significant (p=0.078). In our evaluation of each exon in relationship to survival, p53 mutations in exon 7 correlated significantly with poor prognosis (p=0.041). In multivariate analysis, p53 mutation emerged as an independent marker for prognostic hazard ratio= 1.650 (p=0.015). However, exon 7 mutations were not related to survival, as well other exons and specific type of mutations. Investigation of p53 mutation overall was considered to be a clinically usefull approach for determining the prognosis of patients with colorectal cancer.", "subitem_description_type": "Abstract"}]}, "item_5_description_7": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "弘前医学. 56(2/3/4), 2005, 69-78", "subitem_description_type": "Other"}]}, "item_5_full_name_2": {"attribute_name": "著者(ヨミ)", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "11278", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ワタナベ, トモコ"}]}, {"nameIdentifiers": [{"nameIdentifier": "11279", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "タムラ, ヨシヒロ"}]}, {"nameIdentifiers": [{"nameIdentifier": "11280", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ツシマ, ケンイチ"}]}, {"nameIdentifiers": [{"nameIdentifier": "11078", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ムナカタ, アキヒロ"}]}]}, "item_5_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "11274", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "渡邉, 智子"}]}, {"nameIdentifiers": [{"nameIdentifier": "11275", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "田村, 好弘"}]}, {"nameIdentifiers": [{"nameIdentifier": "11276", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "対馬, 健一"}]}, {"nameIdentifiers": [{"nameIdentifier": "11074", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "棟方, 昭博"}]}]}, "item_5_publisher_35": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "弘前大学医学部・弘前医学会"}]}, "item_5_radio_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_radio_item": "Article"}]}, "item_5_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00211444", "subitem_source_identifier_type": "NCID"}]}, "item_5_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0439-1721", "subitem_source_identifier_type": "ISSN"}]}, "item_5_subject_19": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "490", "subitem_subject_scheme": "NDC"}]}, "item_5_subject_23": {"attribute_name": "NIIサブジェクト", "attribute_value_mlt": [{"subitem_subject": "内科系臨床医学", "subitem_subject_scheme": "Other"}]}, "item_5_text_4": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "First Department of Internal Medicine, Hirosaki University School of Medicine"}, {"subitem_text_value": "弘前大学医学部内科学第一講座"}]}, "item_5_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Watanabe, Tomoko"}], "nameIdentifiers": [{"nameIdentifier": "11270", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tamura, Yoshihiro"}], "nameIdentifiers": [{"nameIdentifier": "11271", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsushima, Kenichi"}], "nameIdentifiers": [{"nameIdentifier": "11272", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Munakata, Akihiro"}], "nameIdentifiers": [{"nameIdentifier": "11082", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-03-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004190601.pdf", "filesize": [{"value": "647.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 647400.0, "url": {"label": "KJ00004190601.pdf", "url": "https://hirosaki.repo.nii.ac.jp/record/3583/files/KJ00004190601.pdf"}, "version_id": "77d211d8-9865-40b0-8f9b-0c762a57c6d0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "colorectal cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53 mutation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "direct sequencing method", "subitem_subject_scheme": "Other"}, {"subitem_subject": "大腸癌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53遺伝子変異", "subitem_subject_scheme": "Other"}, {"subitem_subject": "直接シークエンス法", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Prognostic Significance of P53 Mutation in Surgically Treated Colorectal Cancer : A Prospective Study Using Direct Sequencing Method", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Prognostic Significance of P53 Mutation in Surgically Treated Colorectal Cancer : A Prospective Study Using Direct Sequencing Method"}]}, "item_type_id": "5", "owner": "3", "path": ["637"], "permalink_uri": "http://hdl.handle.net/10129/73", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-12-07"}, "publish_date": "2006-12-07", "publish_status": "0", "recid": "3583", "relation": {}, "relation_version_is_last": true, "title": ["Prognostic Significance of P53 Mutation in Surgically Treated Colorectal Cancer : A Prospective Study Using Direct Sequencing Method"], "weko_shared_id": 3}
Prognostic Significance of P53 Mutation in Surgically Treated Colorectal Cancer : A Prospective Study Using Direct Sequencing Method
http://hdl.handle.net/10129/73
http://hdl.handle.net/10129/738b314a95-caac-4eca-a102-5312135c7183
名前 / ファイル | ライセンス | アクション |
---|---|---|
KJ00004190601.pdf (647.4 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2006-12-07 | |||||
タイトル | ||||||
タイトル | Prognostic Significance of P53 Mutation in Surgically Treated Colorectal Cancer : A Prospective Study Using Direct Sequencing Method | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | colorectal cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53 mutation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | direct sequencing method | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 大腸癌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53遺伝子変異 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 直接シークエンス法 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Watanabe, Tomoko
× Watanabe, Tomoko× Tamura, Yoshihiro× Tsushima, Kenichi× Munakata, Akihiro |
|||||
著者(ヨミ) | ||||||
姓名 | ワタナベ, トモコ | |||||
著者(ヨミ) | ||||||
姓名 | タムラ, ヨシヒロ | |||||
著者(ヨミ) | ||||||
姓名 | ツシマ, ケンイチ | |||||
著者(ヨミ) | ||||||
姓名 | ムナカタ, アキヒロ | |||||
著者別名 | ||||||
姓名 | 渡邉, 智子 | |||||
著者別名 | ||||||
姓名 | 田村, 好弘 | |||||
著者別名 | ||||||
姓名 | 対馬, 健一 | |||||
著者別名 | ||||||
姓名 | 棟方, 昭博 | |||||
著者所属 | ||||||
First Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
弘前大学医学部内科学第一講座 | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To evaluate the clinical significance of p53 mutations, we analyzed the relationship of several clinicopathologic factors to the clinical outcomes in 131 colorectal cancer patients. Exons 5 to 9 of the p53 gene were studied by the direct sequencing method with capillary electrophoresis. A total of 47 mutations of p53 were found, in 45 of 131 cases (34%). Mutations were statistically associated with lymphatic invasion (p=0.03) and lymph node metastasis (p=0.02). Kaplan-Meier survival curves for the patients with p53 mutations were likely to exhibit shortened survivals, but the difference was not statistically significant (p=0.078). In our evaluation of each exon in relationship to survival, p53 mutations in exon 7 correlated significantly with poor prognosis (p=0.041). In multivariate analysis, p53 mutation emerged as an independent marker for prognostic hazard ratio= 1.650 (p=0.015). However, exon 7 mutations were not related to survival, as well other exons and specific type of mutations. Investigation of p53 mutation overall was considered to be a clinically usefull approach for determining the prognosis of patients with colorectal cancer. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 56(2/3/4), 2005, 69-78 | |||||
書誌情報 |
弘前医学 巻 56, 号 2/3/4, p. 69-78, 発行日 2005-03-31 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
その他のタイトル | ||||||
その他のタイトル | 直接シークエンス法による大腸癌手術症例におけるp53遺伝子変異の予後の検討 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | チョクセツ シークエンスホウ ニヨル ダイチョウガン シュジュツ ショウレイ ニオケル p53 イデンシ ヘンイ ノ ヨゴ ノ ケントウ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 内科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学医学部・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |