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An Immunohistochemical Evaluation of Enzymes in Metaplastic Paneth Cells in Ulcerative Colitis
http://hdl.handle.net/10129/192
http://hdl.handle.net/10129/192591ebefe-8034-4fa1-8229-f8541b5d7efd
名前 / ファイル | ライセンス | アクション |
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KJ00004529547.pdf (744.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-01 | |||||
タイトル | ||||||
タイトル | An Immunohistochemical Evaluation of Enzymes in Metaplastic Paneth Cells in Ulcerative Colitis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | パネート細胞化生 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 潰瘍性大腸炎 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 免疫組織化学 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Paneth cell metaplasia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ulcerative colitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunohistochemistry | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Murata, Azuma
× Murata, Azuma× Tanaka, Masanori× Kusumi, Tomomi× Kudo, Hajime |
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著者(ヨミ) | ||||||
姓名 | ムラタ, アズマ | |||||
著者(ヨミ) | ||||||
姓名 | タナカ, マサヒロ | |||||
著者(ヨミ) | ||||||
姓名 | クスミ, トモミ | |||||
著者(ヨミ) | ||||||
姓名 | クドウ, ハジメ | |||||
著者別名 | ||||||
姓名 | 村田, 東 | |||||
著者別名 | ||||||
姓名 | 田中, 正則 | |||||
著者別名 | ||||||
姓名 | 楠美, 智巳 | |||||
著者別名 | ||||||
姓名 | 工藤, 一 | |||||
著者所属 | ||||||
Second Department of Pathology, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Second Department of Pathology, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Second Department of Pathology, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Second Department of Pathology, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
弘前大学医学部病理学第二講座 | ||||||
著者所属 | ||||||
弘前大学医学部病理学第二講座 | ||||||
著者所属 | ||||||
弘前大学医学部病理学第二講座 | ||||||
著者所属 | ||||||
弘前大学医学部病理学第二講座 | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Innate Paneth cells (IPCs) contain various enzymes such as matrix metalloproteinase-7 (MMP7), lysozyme, secretory phospholipase A_2 (sPLA_2), and α_1-antitrypsin (α_1AT), which are considered to participate in important roles against bacteria and mucosal injury, while it is unknown whether metaplastic Paneth cells (MPCs) in ulcerative colitis (UC) have similar functions to IPCs. An immunohistochemical comparison between IPCs and MPCs was made using antibodies against these enzymes. The study included 20 patients with total colitis type of active UC. For six segments from the cecum to the rectum, ratios of the number of MPCs with enzyme positive granules (enzyme^+-MPCs) and ratios of the number of MPCs with positive granules occupying more than a half of the cytoplasm (enzyme^<1/2>-MPCs) to that of all MPCs were calculated. The populations of MMP7^+-MPCs, MMP7^<1/2>-MPCs and lysozyme^<1/2>-MPCs were significantly smaller than those of IPCs in the ileum taken from 20 controls (p<0.01). Both MPCs and IPCs abundantly contained sPLA_2 positive granules, but had few α_1AT granules. MPCs were characterized by scant MMP7 and abundant sPLA_2; MMP7 is capable of causing tissue injury and sPLA_2 is associated with mucosal repair. Although a population of MPCs is usually small in the colorectal mucosa of UC, they are suggested to come into existence to play a role of mucosal repair. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 57(1), 2005, p.9-16 | |||||
書誌情報 |
弘前医学 巻 57, 号 1, p. 9-16, 発行日 2005-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 491.6 | |||||
その他のタイトル | ||||||
その他のタイトル | 潰瘍性大腸炎の化生性パネート細胞に含まれる酵素に関する免疫組織化学的検討 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | カイヨウセイ ダイチョウエン ノ カセイセイ パネート サイボウ ニ フクマレル コウソ ニ カンスル メンエキ ソシキ カガクテキ ケントウ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 基礎医学 | |||||
出版者 | ||||||
出版者 | 弘前大学医学部・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |