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Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications
http://hdl.handle.net/10129/2223
http://hdl.handle.net/10129/2223cbb1e9c6-6c1b-4f91-a2d6-24abb7bd68b7
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_59_S101.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-09-18 | |||||
タイトル | ||||||
タイトル | Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diabetes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vasculopathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuropathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PPAR-γ | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yagihashi, Soroku
× Yagihashi, Soroku× Yamagishi, Shin-Ichiro× Mizukami, Hiroki× Wada, Ryuichi |
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著者所属 | ||||||
Department of Molecular Pathology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Molecular Pathology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Molecular Pathology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Molecular Pathology, Hirosaki University Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Accumulating evidence supports that proinflammatory processes are implicated in the establishment of characteristic pathology in diabetic vascular and neurological complications. Altered cellular signaling during inflammatory processes is a new target for the treatment of diabetic complications and there appear to be some attempts to explore the eff ects of thiazolidinedione, a ligand of peroxisome proliferating activator receptor( PPAR)-γ for not only the treatment of diabetes itself but for the application to diabetic complications. We therefore explored the eff ects of PPAR-γ agonist, pioglitazone, on the experimental model of diabetic neuropathy. We found that pioglitazone signifi cantly improved nerve conduction velocities and depressed protein kinase C activity. This is a new area for the exploration of eff ective treatment of diabetic complications that pose a considerable socioeconomic burden in the current world. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 59(Suppl.), 2007, p.S101-S108 | |||||
書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S101-S108, 発行日 2007-11-29 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 491 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 基礎医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |