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Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen
http://hdl.handle.net/10129/1792
http://hdl.handle.net/10129/1792f7688c7a-2786-4681-958d-170fa510a1cc
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_60_1-4_1.pdf (816.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-04-08 | |||||
タイトル | ||||||
タイトル | Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene deletion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hair cycle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hair follicle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypotrichosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | keratin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 遺伝子欠失 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 毛周期 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 毛包 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 乏毛症 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ケラチン | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Akita, Miki
× Akita, Miki× Nanashima, Naoki× Yamada, Toshiyuki× Nakano, Hajime× Shimizu, Takeshi× Fan, Yang× Tsuchida, Shigeki |
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著者(ヨミ) | ||||||
姓名 | アキタ, ミキ | |||||
著者(ヨミ) | ||||||
姓名 | ナナシマ, ナオキ | |||||
著者(ヨミ) | ||||||
姓名 | ヤマダ, トシユキ | |||||
著者(ヨミ) | ||||||
姓名 | ナカノ, ハジメ | |||||
著者(ヨミ) | ||||||
姓名 | シミズ, タケシ | |||||
著者(ヨミ) | ||||||
姓名 | ツチダ, シゲキ | |||||
著者別名 | ||||||
姓名 | 秋田, 美季 | |||||
著者別名 | ||||||
姓名 | 七島, 直樹 | |||||
著者別名 | ||||||
姓名 | 山田, 俊幸 | |||||
著者別名 | ||||||
姓名 | 中野, 創 | |||||
著者別名 | ||||||
姓名 | 清水, 武史 | |||||
著者別名 | ||||||
姓名 | 范, 洋 | |||||
著者別名 | ||||||
姓名 | 土田, 成紀 | |||||
著者所属 | ||||||
Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Dermatology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科ゲノム生化学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科ゲノム生化学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科ゲノム生化学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科皮膚科学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科ゲノム生化学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科ゲノム生化学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科ゲノム生化学講座 | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The Hirosaki hairless rat (HHR) is a mutant strain spontaneously derived from the Sprague-Dawley rat (SDR) and its inheritance is autosomal recessive. Our recent study has revealed that an 80-kb genomic DNA on 7q36 containing basic hair keratin genes, Kb21, Kb23, Kb26 and Krt2-25, is deleted in HHR. To characterize hair follicles in HHR, progression of hair cycle and expression profi les of basic hair keratins were immunohistochemically studied and compared with those of SDR. The HHR exhibited sparse hairs and their twisted hairs were shorter than SDR hairs. HHR hair follicles entered the catagen phase earlier than SDR and massive destruction of HHR hair follicles and infi ltration of infl ammatory cells occurred in the catagen phase. In HHR the hair medulla was enlarged and the inner root sheath was thinned while the hair cortex was formed where Kb25 was expressed. In SDR Kb25 was expressed in the hair matrix and medulla. Electron microscopy indicated loss of the cuticle in HHR. These results suggest that hypotrichosis of HHR is due to the deletion of hair keratin genes and expression of a keratin fusion gene. Thus, HHR seems to be a useful model to examine the role of hair keratins in the hair follicle formation. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 60(1/2/3/4), 2009, p.1-11 | |||||
書誌情報 |
弘前医学 巻 60, 号 1/2/3/4, p. 1-11, 発行日 2009-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 494.8 | |||||
その他のタイトル | ||||||
その他のタイトル | 塩基性へアケラチン遺伝子群を欠失する弘前ヘアレスラットの毛包の性質:毛髄質の拡大と毛小皮の欠損,退行期の延長 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | エンキセイ エ アケラチン イデンシグン オ ケッシツスル ヒロサキ エ アレスラット ノ ケガワ ノ セイシツ : モウズイシツ ノ カクダイ ト モウショウヒ ノ ケッソン タイコウキ ノ エンチョウ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 外科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |