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Bradykinin increased coronary fl ow( CF) dosedependently\nand this was not aff ected by NG-nitro-L-arginine methyl ester or indomethacin, indicating that bradykinin’s\neff ect on CF was not mediated by nitric oxide or prostacyclin but by EDHF. Bradykinin-induced CF increase was smaller\nin SHR than in WKY. Tetrabutylammonium( a non-specific KCa channel blocker) abolished bradykinin-induced CF\nincrease in both rats. 1-Ethyl-2-benzimedazolinone( 1-EBIO, an agonist of intermediate conductance KCa channel)-induced\nincrease in CF was smaller in SHR than in WKY. 1,3-Dihydro-1-[2-hydroxy-5(- trifl uoromethyl) phenyl]-5(- trifl uoromethyl)\n-2H-benzimidazol-2-one( NS1619, an agonist of large conductance KCa channel)-induced increase in CF did not differ\nbetween SHR and WKY. In early stage of hypertension, there was no signifi cant diff erence between SHR and WKY in\nbradykinin- and 1-EBIO-induced increases in CF. 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Impairment of Calcium-Activated Potassium Channels in Endothelium-Derived Hyperpolarizing Factor Responses in Spontaneously Hypertensive Rats
http://hdl.handle.net/10129/1801
http://hdl.handle.net/10129/18017a600a25-77fb-4651-abd4-d21507c6c0b9
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_60_1-4_86.pdf (529.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-04-09 | |||||
タイトル | ||||||
タイトル | Impairment of Calcium-Activated Potassium Channels in Endothelium-Derived Hyperpolarizing Factor Responses in Spontaneously Hypertensive Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Endothelium-derived hyperpolarizing factor (EDHF) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Coronary microcirculation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calcium-activated potassium channel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hypertension | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 内皮依存性過分極因子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 冠微小循環 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | カルシウム活性化カリウムチャネル | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 高血圧 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hasegawa, Kazushi
× Hasegawa, Kazushi× Oikawa, Koichi× Yoshida, Ikko× Ishizaka, Hiroshi× Osanai, Tomohiro× Motomura, Shigeru× Okumura, Ken |
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著者(ヨミ) | ||||||
姓名 | ハセガワ, カズシ | |||||
著者(ヨミ) | ||||||
姓名 | オイカワ, コウイチ | |||||
著者(ヨミ) | ||||||
姓名 | ヨシダ, イッコウ | |||||
著者(ヨミ) | ||||||
姓名 | イシザカ, ヒロシ | |||||
著者(ヨミ) | ||||||
姓名 | オサナイ, トモヒロ | |||||
著者(ヨミ) | ||||||
姓名 | モトムラ, シゲル | |||||
著者(ヨミ) | ||||||
姓名 | オクムラ, ケン | |||||
著者別名 | ||||||
姓名 | 長谷川, 一志 | |||||
著者別名 | ||||||
姓名 | 及川, 広一 | |||||
著者別名 | ||||||
姓名 | 吉田, 一弘 | |||||
著者別名 | ||||||
姓名 | 石坂, 浩 | |||||
著者別名 | ||||||
姓名 | 長内, 智宏 | |||||
著者別名 | ||||||
姓名 | 元村, 成 | |||||
著者別名 | ||||||
姓名 | 奥村, 謙 | |||||
著者所属 | ||||||
Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Pharmacology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To examine the effect of chronic hypertension on endothelium-derived hyperpolarizing factor( EDHF) responses, the hearts of Wistar-Kyoto rats( WKY) and spontaneously hypertensive rats( SHR) were isolated and perfused using Langendorff system with constant perfusion pressure. Bradykinin increased coronary fl ow( CF) dosedependently and this was not aff ected by NG-nitro-L-arginine methyl ester or indomethacin, indicating that bradykinin’s eff ect on CF was not mediated by nitric oxide or prostacyclin but by EDHF. Bradykinin-induced CF increase was smaller in SHR than in WKY. Tetrabutylammonium( a non-specific KCa channel blocker) abolished bradykinin-induced CF increase in both rats. 1-Ethyl-2-benzimedazolinone( 1-EBIO, an agonist of intermediate conductance KCa channel)-induced increase in CF was smaller in SHR than in WKY. 1,3-Dihydro-1-[2-hydroxy-5(- trifl uoromethyl) phenyl]-5(- trifl uoromethyl) -2H-benzimidazol-2-one( NS1619, an agonist of large conductance KCa channel)-induced increase in CF did not differ between SHR and WKY. In early stage of hypertension, there was no signifi cant diff erence between SHR and WKY in bradykinin- and 1-EBIO-induced increases in CF. In conclusion, EDHF response in coronary microcirculation is impaired in SHR due to dysfunction of intermediate-conductance calcium-activated potassium channels. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 60(1/2/3/4), 2009, p.86-95 | |||||
書誌情報 |
弘前医学 巻 60, 号 1/2/3/4, p. 86-95, 発行日 2009-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 493.2 | |||||
その他のタイトル | ||||||
その他のタイトル | 高血圧自然発症ラットの内皮依存性過分極因子反応におけるカルシウム活性化カリウムチャネルの障害 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | コウケツアツ シゼン ハッショウ ラット ノ ナイヒ イゾンセイ カブン キョクインシ ハンノウ ニオケル カルシウム カッセイカ カリウム チャネル ノ ショウガイ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 内科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |