WEKO3
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Changes in coronary fl ow to adenosine, pinacidil and sodium nitroprusside\n(SNP) were examined before and after administration of glibenclamide( 10-7 M), or NG-nitro-L-arginine methyl ester\n(L-NAME, 10-4 M).\n Results At the age of 32 weeks, adenosine- and pinacidil-induced increases in coronary fl ow were blunted in OLETF\nas compared with those in LETO (both p\u003c0.05). Glibenclamide attenuated adenosine-induced increase in coronary\nfl ow in LETO (p\u003c0.05), but not in OLETF. In contrast, L-NAME attenuated adenosine-induced increase in coronary\nflow in OLETF (p\u003c0.05), but not in LETO. SNP-induced increases in coronary flow in LETO and OLETF were\ncomparable and were not aff ected by glibenclamide. In 8-week-old OLETF and LETO, no diff erence was observed in\nadenosine-, pinacidil- and SNP-induced increases in coronary fl ow between OLETF and LETO.\n Conclusions In this type 2 DM model, KATP channel function in coronary microcirculation is impaired. 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Adenosine-Induced Dilation of Coronary Resistance Vessels Is Impaired in Rats with Type 2 Diabetes Mellitus: Possible Role of ATP-Sensitive Potassium Channels and Nitric Oxide
http://hdl.handle.net/10129/3275
http://hdl.handle.net/10129/327533957ed5-ba82-43e6-9ed7-2985daad366f
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_61(1)_8.pdf (403.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-03-29 | |||||
タイトル | ||||||
タイトル | Adenosine-Induced Dilation of Coronary Resistance Vessels Is Impaired in Rats with Type 2 Diabetes Mellitus: Possible Role of ATP-Sensitive Potassium Channels and Nitric Oxide | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adenosine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diabetes mellitus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microcirculation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nitric oxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アデノシン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 糖尿病 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 微小循環 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 一酸化炭素 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshida, Ikko
× Yoshida, Ikko× Ishizaka, Hiroshi× Hasegawa, Kazushi× Satoh, Kiyohiko× Osanai, Tomohiro× Motomura, Shigeru× Okumura, Ken |
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著者(ヨミ) | ||||||
姓名 | ヨシダ, イッコウ | |||||
著者(ヨミ) | ||||||
姓名 | イシザカ, ヒロシ | |||||
著者(ヨミ) | ||||||
姓名 | ハセガワ, カズシ | |||||
著者(ヨミ) | ||||||
姓名 | サトウ, キヨヒコ | |||||
著者(ヨミ) | ||||||
姓名 | オサナイ, トモヒロ | |||||
著者(ヨミ) | ||||||
姓名 | モトムラ, シゲル | |||||
著者(ヨミ) | ||||||
姓名 | オクムラ, ケン | |||||
著者別名 | ||||||
姓名 | 吉田, 一弘 | |||||
著者別名 | ||||||
姓名 | 石坂, 浩 | |||||
著者別名 | ||||||
姓名 | 長谷川, 一志 | |||||
著者別名 | ||||||
姓名 | 佐藤, 清彦 | |||||
著者別名 | ||||||
姓名 | 長内, 智宏 | |||||
著者別名 | ||||||
姓名 | 元村, 成 | |||||
著者別名 | ||||||
姓名 | 奥村, 謙 | |||||
著者所属 | ||||||
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Pharmacology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives The purpose of this study was to test the hypothesis that adenosine-induced coronary microvascular dilation is blunted in the animals with diabetes mellitus( DM) through the impairment of KATP channel function. Background Adenosine-induced coronary vasodilation is demonstrated to be mediated by activation of ATPsensitive potassium( KATP) channels and nitric oxide( NO). Methods The hearts of Otsuka Long-Evans Tokushima fatty rats (OLETF, type 2 DM rats), and control Long- Evans Tokushima fatty rats( LETO) at the ages of 32 and 8 weeks were perfused using a Langendorff system with constant perfusion pressure (80 mmHg). Changes in coronary fl ow to adenosine, pinacidil and sodium nitroprusside (SNP) were examined before and after administration of glibenclamide( 10-7 M), or NG-nitro-L-arginine methyl ester (L-NAME, 10-4 M). Results At the age of 32 weeks, adenosine- and pinacidil-induced increases in coronary fl ow were blunted in OLETF as compared with those in LETO (both p<0.05). Glibenclamide attenuated adenosine-induced increase in coronary fl ow in LETO (p<0.05), but not in OLETF. In contrast, L-NAME attenuated adenosine-induced increase in coronary flow in OLETF (p<0.05), but not in LETO. SNP-induced increases in coronary flow in LETO and OLETF were comparable and were not aff ected by glibenclamide. In 8-week-old OLETF and LETO, no diff erence was observed in adenosine-, pinacidil- and SNP-induced increases in coronary fl ow between OLETF and LETO. Conclusions In this type 2 DM model, KATP channel function in coronary microcirculation is impaired. Adenosineinduced increase in coronary fl ow is mediated mainly by NO mechanism. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 61(1), 2010, p.8-18 | |||||
書誌情報 |
弘前医学 巻 61, 号 1, p. 8-18, 発行日 2010-03-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 493.1 | |||||
その他のタイトル | ||||||
その他のタイトル | アデノシン誘発性冠抵抗血管の拡張は2型糖尿病ラットで障害されている : ATP 感受性Kチャネルと一酸化窒素の役割 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | アデノシン ユウハツセイ カンテイコウ ケッカン ノ カクチョウ ワ ニガタ トウニョウビョウ ラット デ ショウガイ サレテイル ATP カンジュセイ Kチャネル ト イッサンカ チッソ ノ ヤクワリ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 内科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学出版会 | |||||
資源タイプ | ||||||
値 | Article |