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<Poster>15-Deoxy-Δ^12,14-prostaglandin J_2 modifi es profi les of nuclear TDP-43 protein through its direct binding : Implication for the pathogenesis of TDP-43 proteinopathy
http://hdl.handle.net/10129/3689
http://hdl.handle.net/10129/36898d935457-2bb7-4b39-b4dd-3dc9855b6808
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_61_S204.pdf (448.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-19 | |||||
タイトル | ||||||
タイトル | <Poster>15-Deoxy-Δ^12,14-prostaglandin J_2 modifi es profi les of nuclear TDP-43 protein through its direct binding : Implication for the pathogenesis of TDP-43 proteinopathy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Amyotrophic lateral sclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Frontotemporal lobar degeneration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 15d-PGJ2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prostaglandin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TDP-43 proteinopathy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Zhang, Hai-xin
× Zhang, Hai-xin× Tanji, Kunikazu× Yoshida, Hidemi× Hayakari, Makoto× Mori, Fumiaki× Wakabayashi, Koichi |
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著者(ヨミ) | ||||||
姓名 | タンジ, クニカズ | |||||
著者(ヨミ) | ||||||
姓名 | ヨシダ, ヒデミ | |||||
著者(ヨミ) | ||||||
姓名 | ハヤカリ, マコト | |||||
著者(ヨミ) | ||||||
姓名 | モリ, フミアキ | |||||
著者(ヨミ) | ||||||
姓名 | ワカバヤシ, コウイチ | |||||
著者別名 | ||||||
姓名 | 丹治, 邦和 | |||||
著者別名 | ||||||
姓名 | 吉田, 秀見 | |||||
著者別名 | ||||||
姓名 | 早狩, 誠 | |||||
著者別名 | ||||||
姓名 | 森, 文秋 | |||||
著者別名 | ||||||
姓名 | 若林, 孝一 | |||||
著者所属 | ||||||
Departments of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Departments of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Departments of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Pharmaceutical Science, Hirosaki University Hospital | ||||||
著者所属 | ||||||
Departments of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Departments of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | TDP-43 proteinopathy (amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions) is a newly categorized group of neurodegenerative disorders characterized by abnormal accumulation and mislocalization of nuclear TDP-43 protein in the neuronal cytoplasm. 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is non-enzymatically produced from PGD2, and plays roles in infl ammation and oxidative stress responses. Indeed, 15d-PGJ2 is up-regulated in the spinal motor neurons in ALS. In this study, biochemical and fluorescent staining analyses showed that 15d-PGJ2 modifi es expression, solubility, and subcellular localization of TDP-43. This alteration was at least partly related to a cyclopentenone ring structure containing an electrophilic carbon of 15d-PGJ2, because 15d-PGJ2 analogue, which lacks an cyclopentenone ring structure, had almost no eff ect on TDP-43 protein. Finally in vitro binding experiment indicated that 15d-PGJ2 is covalently bound to TDP-43 protein. These fi ndings suggest that a sustained high level of 15d-PGJ2 is involved in the pathogenesis of neurodegenerative disorders related to abnormal TDP-43 protein. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 61(Suppl.), 2010, p.S204-S210 | |||||
書誌情報 |
弘前医学 巻 61, 号 Supplement, p. S204-S210, 発行日 2010-07-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |