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Pretreatment of Renal Supscapular Administration of Adipose Tissue-derived Stem Cells Ameliorate Ischemiareperfusion-Induced Acute Kidney Injury
http://hdl.handle.net/10129/4861
http://hdl.handle.net/10129/4861d9d6721a-4e6b-4cd1-be11-102abe9abc9b
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_64_S6.pdf (345.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-30 | |||||
タイトル | ||||||
タイトル | Pretreatment of Renal Supscapular Administration of Adipose Tissue-derived Stem Cells Ameliorate Ischemiareperfusion-Induced Acute Kidney Injury | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ADIPOSE TISSUE-DERIVED STEM CELLS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ISCHEMIA-REPERFUSION-INDUCED ACUTE KIDNEY INJURY | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RENAL PROTECT | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CYTOKINES | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamamoto, Tokunori
× Yamamoto, Tokunori× Funahashi, Yasuto× Mastukawa, Yoshihisa× Kato, Masashi× Yoshino, Yasushi× Gotoh, Momokzu |
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著者(ヨミ) | ||||||
姓名 | ヤマモト, トクノリ | |||||
著者(ヨミ) | ||||||
姓名 | フナハシ, ヤスト | |||||
著者(ヨミ) | ||||||
姓名 | マツカワ, ヨシヒサ | |||||
著者(ヨミ) | ||||||
姓名 | カトウ, マサシ | |||||
著者(ヨミ) | ||||||
姓名 | ヨシノ, ヤスシ | |||||
著者(ヨミ) | ||||||
姓名 | ゴトウ, モモカズ | |||||
著者所属 | ||||||
Department of Urology, Nagoya University | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background Acute renal ischemic injury (AKI) represents a major clinical problem with renal arterial clamp at partial nephrectomy. The use of therapy using adipose tissue-derived stem cells(ASCs) has been suggested as a potential modality to attenuate the ischemic renal damage. Methods We investigated the possible reno-protection of pretreatment of ASCs before and after in a rat ischemia–reperfusion (I–R) model of AKI. Twenty-four hours post-ischemia, blood flow in peritubular capillaries (PTC) was measured using intravital videomicroscopy. Results We demonstrated that ADRC therapy significantly reduced serum creatinine and BUN. Histological analysis further validated a significantly attenuated tubular damage. Intravital videomicroscopy and measurement of red blood cell velocity in peritubular capillaries showed ASCs-injected kidneys displayed significant hemodynamic improvement. Conclusions The subscapular administration of ASCs to the kidney attenuates I/R renal injury though anti-inflammation, antiapotoyic effect and peritubular capillary microcirculation. The present study suggests that ASCs would be a useful tool in preventing ischemic kidney damage in the clinical setting. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 64(Suppl.), 2013, p.S6-S8 | |||||
書誌情報 |
弘前医学 巻 64, 号 Supplement, p. S6-S8, 発行日 2013-04-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |