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Formation and Degradation of Microscopic Globular Body : A Proteinaceous Spheron Originated from Dendrite
http://hdl.handle.net/10129/4871
http://hdl.handle.net/10129/48712e302763-6b1d-446f-b440-8961a126f7ae
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_64_S81.pdf (223.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-30 | |||||
タイトル | ||||||
タイトル | Formation and Degradation of Microscopic Globular Body : A Proteinaceous Spheron Originated from Dendrite | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cathepsin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dendrite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunohistochemistry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lysosome-protease system | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microscopic globular body | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Odagiri, Saori
× Odagiri, Saori× Mori, Fumiaki× Tanji, Kunikazu× Kuroda, Naohito× Wakabayashi, Koichi |
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著者(ヨミ) | ||||||
姓名 | オダギリ, サオリ | |||||
著者(ヨミ) | ||||||
姓名 | モリ, フミアキ | |||||
著者(ヨミ) | ||||||
姓名 | タンジ, クニカズ | |||||
著者(ヨミ) | ||||||
姓名 | クロダ, ナオヒト | |||||
著者(ヨミ) | ||||||
姓名 | ワカバヤシ, コウイチ | |||||
著者別名 | ||||||
姓名 | 小田桐, 紗織 | |||||
著者別名 | ||||||
姓名 | 森, 文秋 | |||||
著者別名 | ||||||
姓名 | 丹治, 邦和 | |||||
著者別名 | ||||||
姓名 | 黒田, 直人 | |||||
著者別名 | ||||||
姓名 | 若林, 孝一 | |||||
著者所属 | ||||||
Departments of Neuropathology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Departments of Neuroanatomy, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Departments of Cell Biology and Histology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Departments of Forensic Medicine, Hirosaki University Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Microscopic globular bodies (MGBs) are eosinophilic spherical inclusions, 1-10 μm in diameter and are located in dendrites. Although MGBs are distributed widely in the gray matter, they are most frequent and numerous in the cerebral neocortex and hippocampus. They are found in the human subjects with and without neurological diseases, ranging in age from 1 to 99 years. Previous histochemical studies have shown that MGBs consist of a proteinaceous component. Recently, we immunohistochemically examined the hippocampus from five control subjects. The marginal portion of MGBs was positive for lysosomal proteases( cathepsins B, D and L), and markers of dendrite( MAP2) and dendritic spine( drebrin). They were negative for ubiquitin, ubiquitin-proteasome system (p62, NUB1 and EDD1), autophagosome (LC3), cytoskeletal proteins (neurofilament, actin, tubulin and cytokeratin), tau, α-synuclein and TDP-43. These findings suggest that MGBs are sequestered by lysosome-protease system, but not by ubiquitin-proteasome system or autophagosome. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 64(Suppl.), 2013, p.S81-S85 | |||||
書誌情報 |
弘前医学 巻 64, 号 Supplement, p. S81-S85, 発行日 2013-04-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |