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Beneficial Effect of 4-Methylumbelliferone Against Bile Duct Ligation-Induced Hepatic Fibrosis in Rats
http://hdl.handle.net/10129/5810
http://hdl.handle.net/10129/5810f978e3b3-cda7-498f-b4ce-334ce1e4ce96
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_66(2-4)_143.pdf (970.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-03-31 | |||||
タイトル | ||||||
タイトル | Beneficial Effect of 4-Methylumbelliferone Against Bile Duct Ligation-Induced Hepatic Fibrosis in Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hyaluronan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 4-methylumbelliferone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alpha-smooth muscle actin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatic stellate cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sawada, Naoya
× Sawada, Naoya× Mikami, Kenichiro× Igarashi, Go× Endo, Tetsu× Sato, Ken× Kakizaki, Ikuko× Fukuda, Shinsaku |
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著者所属 | ||||||
Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Glycotechnology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background & Aims: Liver fibrosis progresses to cirrhosis as the consequence of chronic liver injury. 4-methylumbelliferone (4-MU), a derivative of coumarin, has been used as an approved drug to treat biliary spasm. Recent publications have reported that 4-MU inhibits production of hyaluronan (HA), which is a key component of extracellular matrix deposition in fibrotic and cirrhotic liver. We investigated the effect of 4-MU on fibrotic liver in rats. Methods: Liver fibrosis was induced by bile duct ligation( BDL). Male Sprague-Dawley rats received a standard diet or the same diet containing 1% or 5% of 4-MU from 1 week before BDL. The rats were sacrificed at 3 weeks after BDL. Results: Administration of 4-MU increased serum 4-MU concentration levels, thereby decreasing serum HA levels in a dose-dependent manner. 4-MU treatment suppressed liver fibrosis in interlobular and pericentral areas with reduced alpha-smooth muscle actin expression, which suggested hepatic stellate cell activation. Conclusion: Treatment with 4-MU suppressed the experimental hepatic fibrosis accompanied by inhibition of HA production. Although further experimental studies are needed, 4-MU could protect against fibrogenesis and may be repurposed as a safe therapeutic application for hepatic fibrosis. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 66, 2016, p.143-151 | |||||
書誌情報 |
弘前医学 巻 66, 号 2-4, p. 143-151, 発行日 2016-03-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |