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Effects of Halothane Anesthesia on Electrocardiogram Parameters in Mice
http://hdl.handle.net/10129/6012
http://hdl.handle.net/10129/60124b060dd3-0848-4c56-8393-76a9bdefb2d4
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_67(2-4)_129.pdf (240.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-03-09 | |||||
タイトル | ||||||
タイトル | Effects of Halothane Anesthesia on Electrocardiogram Parameters in Mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inhalation halothane anesthesia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | barbiturate; mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ECG | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nozaki, Shuhei
× Nozaki, Shuhei× Ogata, Yoshiki× Yonekura, Manabu× Han, Chong× Niwa, Hidetoshi× Kushikata, Tetsuya× Hirota, Kazuyoshi× Matsuzaki, Yasushi× Tomita, Hirofumi× Imaizumi, Tadaatsu× Itagaki, Shirou× Sawamura, Daisuke× Murakami, Manabu |
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著者所属 | ||||||
Department of Pharmacology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Pharmacology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Pharmacology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Anesthesiology, Hirosaki UniversityGraduate School of Medicine | ||||||
著者所属 | ||||||
Department of Anesthesiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Anesthesiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Dermatology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Pharmacy, Hirosaki University, Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Dermatology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Pharmacology, Hirosaki UniversityGraduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We analyzed the effects of halothane as an inhalational anesthetic agent on electrocardiogram (ECG) parameters in C57/BL6 mice. Following induction of anesthesia using 2% halothane, the ECGs showed a regular pattern and the heart rate (HR) was within an acceptable range (~500 bpm). The HR decreased with increasing halothane concentration in a concentration-dependent fashion. The frequency domain analysis showed that the high-frequency (HF) component decreased and the lowfrequency (LF) component increased in a concentration-dependent fashion. Therefore, the LF/HF ratio increased with increasing halothane concentration, suggesting effects on the autonomic nervous system. We analyzed the pharmacological response to sympathetic blockade with propranolol, a typical adrenergic β-blocker, under halothane anesthesia. Propranolol administration resulted in a decreased HR; interestingly, intraperitoneal injection of propranolol (120 μg/kg body weight) resulted in arrhythmia (sick sinus syndrome) during anesthesia with 3% halothane. Our results indicate the importance of selecting a suitable anesthetic agent for C57/BL6 mice in pharmacological studies |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 67, 2017, p.129-135 | |||||
書誌情報 |
弘前医学 巻 67, 号 2-4, p. 129-135, 発行日 2017-02-27 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |