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Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer
http://hdl.handle.net/10129/00006547
http://hdl.handle.net/10129/000065473226c209-d9e1-49b4-9d56-76b7dc681c13
名前 / ファイル | ライセンス | アクション |
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oncotarget-61404 (2.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-03-08 | |||||
タイトル | ||||||
タイトル | Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hamano, Itsuto
× Hamano, Itsuto× Hatakeyama, Shingo× Iwamura, Hiromichi× Fujita, Naoki× Fukushi, Ken× Narita, Takuma× Hagiwara, kazuhisa× Kusaka, Ayumu× Hosogoe, Shogo× Yamamoto, Hayato× Tobisawa, Yuki× Yoneyama, Tohru× Yoneyama, Takahiro× Hashimoto, Yasuhiro× Koie, Takuya× Ito, Hiroyuki× Yoshikawa, Kazuaki× Kawaguchi, Toshiaki× Ohyama, Chikara |
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著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Adv Transplant & Regenerat Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Adv Transplant & Regenerat Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Aomori Rosai Hosp, Dept Urol | ||||||
著者所属 | ||||||
Mutsu Gen Hosp, Dept Urol | ||||||
著者所属 | ||||||
Aomori Prefectural Cent Hosp | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncologic outcomes in muscle-invasive bladder cancer patients who underwent radical cystectomy. Methods: A total of 581 patients who underwent radical cystectomy at four medical centers between January 1995 and February 2017 were examined retrospectively. We investigated oncologic outcomes, including progression-free, cancer-specific, and overall survival (PFS, CSS, and OS, respectively) stratified by preoperative CKD status (pre-CKD vs. non-CKD). We performed a Cox proportional hazards regression analysis using inverse probability of treatment weighting (IPTW) to evaluate the impact of preoperative CKD on prognosis and developed the prognostic factor-based risk stratification nomogram. Results: Of the 581 patients, 215 (37%) were diagnosed with CKD before radical cystectomy. Before the background adjustment, PFS, CSS, and OS after radical cystectomy were significantly lower in the pre-CKD group compared to the non-CKD group. Background-adjusted IPTW analysis showed that preoperative CKD was significantly associated with poor PFS, CSS, and OS after radical cystectomy. The nomogram for predicting 5-year PFS and OS probability showed significant correlation with actual PFS and OS (c-index = 0.73 and 0.77, respectively). Conclusions: Muscle-invasive bladder cancer patients with preoperative CKD had a significantly lower survival probability than those without CKD. |
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書誌情報 |
ONCOTARGET 巻 8, 号 37, p. 61404-61414, 発行日 2017-09-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1949-2553 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.18248 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
値 | Article |