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Oncological outcomes of neoadjuvant chemotherapy in patients with locally advanced upper tract urothelial carcinoma: a multicenter study
http://hdl.handle.net/10129/00006551
http://hdl.handle.net/10129/00006551c87e6fae-037b-424f-8e5b-af5f8f63b4e4
名前 / ファイル | ライセンス | アクション |
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oncotarget-101500 (3.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-03-08 | |||||
タイトル | ||||||
タイトル | Oncological outcomes of neoadjuvant chemotherapy in patients with locally advanced upper tract urothelial carcinoma: a multicenter study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kubota, Yuka
× Kubota, Yuka× Hatakeyama, Shingo× Tanaka, Toshikazu× Fujita, Naoki× Iwamura, Hiromichi× Mikami, Jotaro× Yamamoto, Hayato× Tobisawa, Yuki× Yoneyama, Tohru× Yoneyama, Takahiro× Hashimoto, Yasuhiro× Koie, Takuya× Ito, Hiroyuki× Yoshikawa, Kazuaki× Sasaki, Atsushi× Kawaguchi, Toshiaki× Ohyama, Chikara |
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著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
著者所属 | ||||||
Tohoku Med & Pharmaceut Univ, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Adv Transplant & Regenerat Med, Grad Sch Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Adv Transplant & Regenerat Med, Grad Sch Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
著者所属 | ||||||
Aomori Rosai Hosp, Dept Urol, Hachinohe | ||||||
著者所属 | ||||||
Mutsu Gen Hosp, Dept Urol | ||||||
著者所属 | ||||||
Tsugaru Gen Hosp, Dept Urol | ||||||
著者所属 | ||||||
Aomori Prefectural Cent Hosp, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Dept Urol, Grad Sch Med | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: The clinical impact of neoadjuvant chemotherapy (NAC) on oncological outcomes in patients with locally advanced upper tract urothelial carcinoma (UTUC) remains unclear. We investigated the oncological outcomes of platinum-based NAC for locally advanced UTUC. Results: Of 234 patients, 101 received NAC (NAC group) and 133 did not (Control [Ctrl] group). The regimens in the NAC group included gemcitabine and carboplatin (75%), and gemcitabine and cisplatin (21%). Pathological downstagings of the primary tumor and lymphovascular invasion were significantly improved in the NAC than in the Ctrl groups. NAC for locally advanced UTUC significantly prolonged recurrence-free and cancer-specific survival. Multivariate Cox regression analysis using an inverse probability of treatment weighted (IPTW) method showed that NAC was selected as an independent predictor for prolonged recurrence-free and cancer-specific survival. However, the influence of NAC on overall survival was not statistically significant. Materials and Methods: A total of 426 patients who underwent radical nephroureterectomy at five medical centers between January 1995 and April 2017 were examined retrospectively. Of the 426 patients, 234 were treated for a highrisk disease (stages cT3-4 or locally advanced [cN+] disease) with or without NAC. NAC regimens were selected based on eligibility of cisplatin. We retrospectively evaluated post-therapy pathological downstaging, lymphovascular invasion, and prognosis stratified by NAC use. Multivariate Cox regression analysis was performed for independent factors for prognosis. Conclusions: Platinum-based NAC for locally advanced UTUC potentially improves oncological outcomes. Further prospective studies are needed to clarify the clinical benefit of NAC for locally advanced UTUC. |
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書誌情報 |
ONCOTARGET 巻 8, 号 60, p. 101500-101508, 発行日 2017-11-24 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1949-2553 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.21551 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
値 | Article |