Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Anesthesiology, Hirosaki UniversityGraduate School of Medicine
Department of Anesthesiology, Hirosaki UniversityGraduate School of Medicine
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
Department of Anesthesiology, Hirosaki University Graduate School of Medicine
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
抄録
We examined the effects of enflurane anesthesia on the mouse cardiac autonomic nervous system using
electrocardiogram（ ECG） analysis. Enflurane had a lower effect on heart rate（ HR） compared to isoflurane, which is
more widely used in small animal studies. Under anesthesia with 3 or 4% of enflurane, administration of propranolol
had a significant effect on HR. Enflurane increased R-R interval length in a dose-dependent fashion, and the R-R
interval became unstable at high concentrations. Although HR decreased with high doses of enflurane, we observed
normal sinus rhythm and no arrhythmia. These results suggest that the effect of enflurane anesthesia is acceptable
even though the drug can lead to cardiac instability. No remarkable changes were observed in HR frequency. These results suggest that enflurane anesthesia may be suitable for cardiac autonomic nervous system analysis.
運用指針・許諾書
Effects of Enflurane on Cardiac Autonomic Nervous Activity in Mice
HirosakiMedJ_67(2-4)_153.pdf
(259.8KB)
