2026-03-14T09:27:19Z https://hirosaki.repo.nii.ac.jp/oai

oai:hirosaki.repo.nii.ac.jp:00003614 2023-05-15T10:06:01Z 557:1754615242943:561:642

Changes of Proteoglycan Expression and Glycosaminoglycan Constituents in the Intervillous Space of the Pregnancy-Induced Hypertension Placenta 妊娠高血圧症候群胎盤の絨毛間腔におけるプロテオグリカン発現やグリコサミノグリカン構造の変化 ニンプ コウケツアツ ショウコウグン タイバン ノ ジュモウ カンクウ ニオケル プロテオグリカン ハツゲン ヤ グリコサミノグリカン コウゾウ ノ ヘンカ Matsukura, Daisuke Yokoyama, Yoshihito Tanaka, Kanji Ozaki, Takashi Mizunuma, Hideki 495.6 外科系臨床医学 proteoglycans glycosaminoglycans pregnancy-induced hypertension placenta dermatan sulfate プロテオグリカン グリコサミノグリカン 妊娠高血圧症候群 胎盤 デルマタン硫酸 application/pdf The changes in proteoglycan (PG) expression and glycosaminoglycan (GAG) constituents in the intervillous space of the pregnancy-induced hypertension (PIR) placenta were investigated. PGs and GAGs were purified from the extract of the placental intervillous space by the DEAE-Sephacel column and salt-concentration gradient method. and the GAG sugar chains were released by the actinase and cellulase treatments. The sugar chains from the placentas of normal pregnancy and PIR were compared by cellulose-acetate membrane electrophoresis. No difference was observed in the expressions of hyaluronic acid. heparan sulfate, and chondroitin sulfate. but a clear increase in the expression of dermatan sulfate (DS) in the placenta of the PIR was confirmed. An increase of the DS that specifically activates anticoagulants can be a body reaction to counteract the hemostatic condition observed in PIR. 弘前医学. 59, 2008, p.128-135 弘前大学大学院医学研究科・弘前医学会 2008-03-31 eng departmental bulletin paper VoR http://hdl.handle.net/10129/706 https://hirosaki.repo.nii.ac.jp/records/3614 AN00211444 0439-1721 弘前医学 59 2/3/4 128 135 https://hirosaki.repo.nii.ac.jp/record/3614/files/AN00211444_59_128.pdf application/pdf 1.2 MB 2018-03-13