2026-03-12T11:06:27Z https://hirosaki.repo.nii.ac.jp/oai

oai:hirosaki.repo.nii.ac.jp:00003921 2023-05-15T09:58:08Z 557:1754615242943:561:661

What is Happening in The Ards Piglet Lungs: - The Origin of B-Lines on Ultrasonography - Nishimura, Masayuki Tsubo, Toshihito Hirota, Kazuyoshi 490 医学 B-lines ARDS TTE TEE B-lines are the important signs of pulmonary edema in acute respiratory distress syndrome （ARDS） detected with ultrasonography. We studied the mechanism of the origin and disappearance of B-lines in ARDS piglets using ultrasonography and microscopy. Methods: ARDS was induced by intratracheal administration of 0.1M Hydrochloric Acid （HCl） in 23 anesthetized, ventilated piglets. The occurrence of B-lines was evaluated using transthoracic echography （TTE） and transesophageal echography （TEE）. Changes in B-lines were recorded after a saline infusion into the pleural space, and after pulmonary consolidation developed and reached the pleura. Left lower lobe was excised and lung sections were examined by light microscopy. Results: Following the saline infusion into the pleural space, we observed B-lines fanning out from the visceral pleura. As pulmonary consolidation developed, B-lines disappeared. The structure that B-lines fanned out from was the complex of thickened pleura and sub-pleural interlobular septa surrounded by gas. In the tissue where B-lines disappeared, the thickened sub-pleural interlobular septa were surrounded by cells and liquid. Conclusions: We found that B-lines derive from the complex of thickened pleura and sub-pleural interlobular septa surrounded by gas. B-lines disappeared when the sub-pleural thickened interlobular septa were surrounded by cells and liquid. 弘前医学. 68, p.14-22. 2017 弘前大学大学院医学研究科・弘前医学会 2017-10-05 eng journal article VoR http://hdl.handle.net/10129/6144 https://hirosaki.repo.nii.ac.jp/records/3921 AN00211444 0439-1721 弘前医学 68 1 14 22 https://hirosaki.repo.nii.ac.jp/record/3921/files/HirosakiMedJ_68(1)_14.pdf application/pdf 424.6 kB 2018-03-13