2026-03-12T10:48:29Z https://hirosaki.repo.nii.ac.jp/oai

oai:hirosaki.repo.nii.ac.jp:00004213 2023-05-16T06:36:56Z 557:1754614239215:666:673

Endogenous neuropeptide S tone influences sleep–wake rhythm in rats 内因性神経ペプチドSがラットにおける睡眠覚醒リズムに影響を与える ナイインセイ シンケイ ペプチド S ガ ラット ニオケル スイミン カクセイ リズム ニ エイキョウ オ アタエル Oishi, Masafumi open access 491.37 基礎医学 Neuropeptide S (NPS) is an endogenous peptide that exerts wakefulness promoting, analgesic, and anxiolytic effects when administered exogenously. However, it remains to be determined if endogenous NPS tone is involved in the control of the diurnal sleep–wake cycle, or spontanous behavior.In this study, we examined the effects of the NPS receptor antagonist [D-Cys(tBu)5]NPS (2 and 20 nmol, icv) on physiological sleep and spontaneous locomotor behavior. The higher dose of [D-Cys(tBu)5]NPS decreased the amount of time spent in wakefulness [control 782.5 ± 25.5 min, treatment 751.7 ± 28.1 min; p < 0.05] and increased the time spent in NREMS [control 572.6 ± 17.2 min, treatment 600.2 ± 26.1 min; p < 0.05]. There was no statistically significant difference in time spent in REMS. There were no behavioral changes including abnormal gross motor behavior in response to [D-Cys(tBu)5]NPS administration. Collectively these data suggest an involvement of the endogenous NPS/NPS receptor system in physiological sleep architecture. 掲載誌 Neuroscience Letters, 381, 2014, P.94-97 doi:10.1016/j.neulet.2014.08.031 2015-09-30 eng doctoral thesis http://hdl.handle.net/10129/5665 https://hirosaki.repo.nii.ac.jp/records/4213 1 13 甲1904 博士（医学） 2015-09-30 弘前大学 https://hirosaki.repo.nii.ac.jp/record/4213/files/tdm_1904_oishi.pdf application/pdf 235.4 kB 2018-03-13 https://hirosaki.repo.nii.ac.jp/record/4213/files/tdm_1904_oishi_a2.pdf application/pdf 133.2 kB 2018-03-13 https://hirosaki.repo.nii.ac.jp/record/4213/files/tdm_1904_oishi_a1.pdf application/pdf 248.7 kB 2018-03-13