2026-03-09T17:34:53Z https://hirosaki.repo.nii.ac.jp/oai

oai:hirosaki.repo.nii.ac.jp:00003626 2023-05-16T06:42:49Z 557:1754615242943:561:643

Estrogen receptors in diseases of the immune system Warner, Margaret Gustafsson, Jan-Åke 491.8 基礎医学 application/pdf Estrogen has distinct functions in the immune system where it acts via ERα and HERβ respectively. Surprisingly, the defects in the immune system which develop in the absence of either ERα or ERβ are quite distinct from what develops in the absence of estrogen. We have found by studying mice in which either or both estrogen receptors have been inactivated that the two estrogen receptors play distinct roles in the immune system. Loss of ERβ leads to chronic myeloid leukemia and loss of ERα leads to autoimmune disease. In mice which cannot synthesize estrogen there is also autoimmune disease resembling Sjögren’s Syndrome. We plan to study these mice further with the aim of fi nding the exact sites of action of the two receptors in the immune system and by using specifi c ligands for ERα. or ERβ to examine how specifi c parts of the immune system can be modifi ed. These studies should lead to improved treatment of patients with diseases of the immune system. 弘前医学. 59(Suppl.), 2007, p.S77-S81 journal article 弘前大学大学院医学研究科・弘前医学会 2007-11-29 VoR application/pdf 弘前医学 Supplement 59 S77 S81 AN00211444 0439-1721 https://hirosaki.repo.nii.ac.jp/record/3626/files/HirosakiMedJ_59_S77.pdf http://hdl.handle.net/10129/2220 https://hirosaki.repo.nii.ac.jp/records/3626 eng