2026-03-08T14:07:11Z https://hirosaki.repo.nii.ac.jp/oai

oai:hirosaki.repo.nii.ac.jp:00003664 2023-05-15T09:42:59Z 557:1754615242943:561:644

高血圧自然発症ラットの内皮依存性過分極因子反応におけるカルシウム活性化カリウムチャネルの障害 コウケツアツ シゼン ハッショウ ラット ノ ナイヒ イゾンセイ カブン キョクインシ ハンノウ ニオケル カルシウム カッセイカ カリウム チャネル ノ ショウガイ Impairment of Calcium-Activated Potassium Channels in Endothelium-Derived Hyperpolarizing Factor Responses in Spontaneously Hypertensive Rats Hasegawa, Kazushi Oikawa, Koichi Yoshida, Ikko Ishizaka, Hiroshi Osanai, Tomohiro Motomura, Shigeru Okumura, Ken 493.2 内科系臨床医学 Endothelium-derived hyperpolarizing factor (EDHF) Coronary microcirculation Calcium-activated potassium channel Hypertension 内皮依存性過分極因子 冠微小循環 カルシウム活性化カリウムチャネル 高血圧 application/pdf To examine the effect of chronic hypertension on endothelium-derived hyperpolarizing factor（ EDHF） responses, the hearts of Wistar-Kyoto rats（ WKY） and spontaneously hypertensive rats（ SHR） were isolated and perfused using Langendorff system with constant perfusion pressure. Bradykinin increased coronary fl ow（ CF） dosedependently and this was not aff ected by NG-nitro-L-arginine methyl ester or indomethacin, indicating that bradykinin’s eff ect on CF was not mediated by nitric oxide or prostacyclin but by EDHF. Bradykinin-induced CF increase was smaller in SHR than in WKY. Tetrabutylammonium（ a non-specific KCa channel blocker） abolished bradykinin-induced CF increase in both rats. 1-Ethyl-2-benzimedazolinone（ 1-EBIO, an agonist of intermediate conductance KCa channel）-induced increase in CF was smaller in SHR than in WKY. 1,3-Dihydro-1-[2-hydroxy-5（- trifl uoromethyl） phenyl]-5（- trifl uoromethyl） -2H-benzimidazol-2-one（ NS1619, an agonist of large conductance KCa channel）-induced increase in CF did not differ between SHR and WKY. In early stage of hypertension, there was no signifi cant diff erence between SHR and WKY in bradykinin- and 1-EBIO-induced increases in CF. In conclusion, EDHF response in coronary microcirculation is impaired in SHR due to dysfunction of intermediate-conductance calcium-activated potassium channels. 弘前医学. 60(1/2/3/4), 2009, p.86-95 journal article 弘前大学大学院医学研究科・弘前医学会 2009-03-31 VoR application/pdf 弘前医学 1/2/3/4 60 86 95 AN00211444 0439-1721 https://hirosaki.repo.nii.ac.jp/record/3664/files/HirosakiMedJ_60_1-4_86.pdf http://hdl.handle.net/10129/1801 https://hirosaki.repo.nii.ac.jp/records/3664 eng