2026-03-15T23:27:06Z https://hirosaki.repo.nii.ac.jp/oai

oai:hirosaki.repo.nii.ac.jp:00004163 2023-05-15T10:32:35Z 557:1754614239215:666:671

肝外胆管癌における浸潤性微小乳頭癌とその悪性度 カンガイ タンカンガン ニオケル シンジュンセイ ビショウ ニュウトウガン ト ソノ アクセイド Invasive micropapillary carcinoma of the extrahepatic bile duct and its malignant potential Yoshizawa, Tadashi 493.47 医学 弘前大学 博士（医学） Invasive micropapillary carcinoma (IMPC) was originally described as a distinctive type of invasive carcinoma in the breast, but it has not been recognized as a histological type of the extrahepatic bile duct cancer. The present study demonstrated clinicopathological features and patient prognosis of IMPC. We examined histological reviews of 93 consecutive cases of the extrahepatic bile duct cancer and identified 13 cases which included IMPC component. The component of IMPC ranged from 5 to 60% of the primary tumor tissue, which was mainly detected at the invasive front of the tumor. Of the 13 cases, 12 (92.3%) carcinomas with IMPC showed lymph node metastasis more frequently compared to conventional adenocarcinoma (39.2%, P<0.001). Presence of IMPC component was significantly associated with poor overall survival (P=0.003). In conclusion, extrahepatic bile duct carcinoma with IMPC component showed significant lymphatic invasion, lymph node metastasis, and resulted in poor prognosis. 本文リンク： http://www.spandidos-publications.com/or/32/4/1355 Oncology Reports, 32(4), 2014, p.1355-1361 doctoral thesis Spandidos Publications 2014-08 2014-09-30 application/pdf application/pdf application/pdf Oncology Reports 4 32 1355 1361 甲1866 AA11016405 1021-335X https://hirosaki.repo.nii.ac.jp/record/4163/files/tdm_1866_yoshizawa_a2.pdf https://hirosaki.repo.nii.ac.jp/record/4163/files/tdm_1866_yoshizawa_a1.pdf https://hirosaki.repo.nii.ac.jp/record/4163/files/tdm_1866_yoshizawa.pdf http://hdl.handle.net/10129/5476 https://hirosaki.repo.nii.ac.jp/records/4163 eng 10.3892/or.2014.3394 open access