{"created":"2024-04-29T05:50:34.441730+00:00","id":2000353,"links":{},"metadata":{"_buckets":{"deposit":"849a1b35-284f-441e-a908-fc7ceb4ccb11"},"_deposit":{"created_by":11,"id":"2000353","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000353"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:02000353","sets":["557:561:1713851803406"]},"author_link":[],"control_number":"2000353","item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"51","bibliographicPageStart":"40","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"弘前医学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Hirosaki Medical Journal","bibliographic_titleLang":"en"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The risk of various diseases could be proven or improved by physical activity. It is known that the expression and/or activation of some proteins were up-/down-regulated by exercise. Whereas several studies suggested that exercise-related factors were expressed sex-dependently. Additionally, exercise decreased androgen levels in woman’s plasma, but increased in men. These evidence raise the possibility that there is a sex-related difference in the effect of exercise on several protein expressions and signaling pathways.\nIn this study, proteome analysis of mice serum was performed to identify the different effects of exercise on protein expression and signaling pathways between male and female mice. The wheel-running exercise was performed, and activity counts were analyzed. After the exercise, cardiac blood samples were collected for proteome analysis. Significant alterations in protein expression levels were identified. However, few protein expression levels were commonly affected by exercise in males and females. The protein with the highest increased expression levels was F13a1 in males and Sepiapterin reductase （Spr） in females. The protein with the most decreased expression levels was thioredoxin-like protein 1 （Txnl1） in males and insulin-like growth factor binding protein 1 （Igfbp1）in females. By the orthogonal partial least square-discriminant analysis, the different proteins between males and females were identified as candidate biomarkers of exercise. In gene ontology analysis, there were dissimilar patterns of up- and down-regulation in some biological processes. These results suggested that there were several differences in exercise-dependent signaling pathways between male and female mice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科","subitem_publisher_language":"ja"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article","subitem_radio_language":"en"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2434-4656","subitem_source_identifier_type":"EISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Neurophysiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurophysiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurophysiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Stress Response Science, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Metabolomics Innovation, Hirosaki University Graduate School of Medicine、Department of Anesthesiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurophysiology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomonori, Furukawa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shuji, Shimoyama","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aogi, Kobayashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yota, Tatara","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshikazu, Nikaido","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shinya, Ueno","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-29"}],"filename":"Hirosaki Med J 74-1-4_40.pdf","filesize":[{"value":"505 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hirosaki.repo.nii.ac.jp/record/2000353/files/Hirosaki Med J 74-1-4_40.pdf"},"version_id":"5ad8f4bd-9177-4b37-84d6-88c8b0c2a38a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"forced exercise","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"voluntary exercise","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"proteomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sex-related difference","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sex-related differences in the effect of exercise on protein profiles of serum in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sex-related differences in the effect of exercise on protein profiles of serum in mice","subitem_title_language":"en"}]},"item_type_id":"3","owner":"11","path":["1713851803406"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-04-29"},"publish_date":"2024-04-29","publish_status":"0","recid":"2000353","relation_version_is_last":true,"title":["Sex-related differences in the effect of exercise on protein profiles of serum in mice"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-11-20T00:30:17.245773+00:00"}