{"created":"2024-04-29T07:53:57.285279+00:00","id":2000358,"links":{},"metadata":{"_buckets":{"deposit":"6112d308-2c52-4632-808b-44b730fc226f"},"_deposit":{"created_by":11,"id":"2000358","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000358"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:02000358","sets":["557:561:1713851803406"]},"author_link":[],"control_number":"2000358","item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"107","bibliographicPageStart":"99","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"弘前医学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Hirosaki Medical Journal","bibliographic_titleLang":"en"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: High expression of carbonyl reductase 1 （CBR1） in ovarian cancer inhibits tumor growth and metastasis, although its long-term antitumor effects have not been investigated in detail.\nMethods: Transgenic mice （Tg-mice） overexpressing the mouse Cbr1 （CAG-mCbr1） transgene （Tg） （CAG-mCbr1 Tg-mice） were crossed with carcinogenesis model mice （mouse oviduct-specific glycoprotein （mOvgp1）-T-antigen （TAg） Tg-mice）, which overexpress simian virus 40 （SV40） TAg in reproductive organs, and the resulting individuals were evaluated. Survival was evaluated with a cutoff of 24 weeks. Indicators of tumor size （testicular diameter in males, abdominal circumference in females） and body weights were evaluated at 12–13 weeks.\nResults: There were no significant differences in survival between CAG-mCbr1/mOvgp1-TAg double Tg （dTg）-mice and mOvgp1-TAg Tg-mice （P = 0.992）. Male CAG-mCbr1/mOvgp1-TAg dTg-mice tended to have higher survival rates than in mOvgp1-TAg Tg-mice. Although, female mOvgp1-TAg Tg-mice tended to have higher survival rates than for CAG-mCbr1/mOvgp1-TAg dTg-mice, female body weights and male testicular diameter tended to be larger in mOvgp1-TAg Tg-mice than in WT mice.\nConclusions: The lack of significant differences may be attributed to the strong carcinogenic effect of SV40 T-antigen. Although whether CBR1 has antitumor effects was not established, it may be involved in tumor growth rather than in metastasis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科","subitem_publisher_language":"ja"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article","subitem_radio_language":"en"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2434-4656","subitem_source_identifier_type":"EISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Hirosaki University, Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Hirosaki University, Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Stress Response Science, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Institute for Animal Experimentation, Tohoku University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Hirosaki University, Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yuka, Kadonosawa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Minako, Yokoyama","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yota, Tatara","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ichiro, Miyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshihiko, Araki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshihito, Yokoyama","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hodaka, Fujii","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-29"}],"filename":"Hirosaki Med J 74-1-4_99.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hirosaki.repo.nii.ac.jp/record/2000358/files/Hirosaki Med J 74-1-4_99.pdf"},"version_id":"855f6f7c-2a8c-48e4-911f-268ee226783e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"carbonyl reductase 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reproductive organs","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"crossbreeding experiment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transgenic mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Moderate transgenic expression of CBR1 is not sufficient to prolong life expectancy in an SV40 T-antigen-induced gynecological carcinogenesis mouse model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Moderate transgenic expression of CBR1 is not sufficient to prolong life expectancy in an SV40 T-antigen-induced gynecological carcinogenesis mouse model","subitem_title_language":"en"}]},"item_type_id":"3","owner":"11","path":["1713851803406"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-04-29"},"publish_date":"2024-04-29","publish_status":"0","recid":"2000358","relation_version_is_last":true,"title":["Moderate transgenic expression of CBR1 is not sufficient to prolong life expectancy in an SV40 T-antigen-induced gynecological carcinogenesis mouse model"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-11-20T00:30:22.004325+00:00"}