{"created":"2024-04-29T08:48:47.814185+00:00","id":2000360,"links":{},"metadata":{"_buckets":{"deposit":"4e64f096-9e16-41bb-a728-dc3a227690b6"},"_deposit":{"created_by":11,"id":"2000360","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000360"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:02000360","sets":["557:561:1713851803406"]},"author_link":[],"control_number":"2000360","item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"127","bibliographicPageStart":"117","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"弘前医学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Hirosaki Medical Journal","bibliographic_titleLang":"en"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The bronchial epithelium is the site of initial exposure in lungs to viruses, including severe acute respiratory syndrome coronavirus 2. Stimulator of interferon genes （STING） is a molecule activated by virus-derived DNA. STING activation leads to the induction of type I interferon （IFN） expression, followed by increased expression of IFN-stimulated genes （ISGs）. Retinoic acid-inducible gene-I （RIG-I） and IFN-induced transmembrane protein 1 （IFITM1） are  ISGs important in antiviral immunity. However, the interaction between STING and RIG-I/ IFITM1 in bronchial epithelium is not fully understood. We found that the STING agonist diamidobenzimidazole （diABZI） upregulated RIG-I and IFITM1 expression in BEAS-2B. Knockdown of STING decreased diABZI-induced IFN-βexpression and the phosphorylation of signal transducer and activator of transcription （STAT） 1, while treatment with recombinant human IFN-β upregulated the expression level of RIG-I and IFITM1. These data indicate that activation of STING/IFN-β axis upregulates the levels of RIG-I and IFITM1 in bronchial epithelium, activating RNA virus sensing pathway, inhibiting virus entry into cells. This study contributes to the discovery of new therapeutic targets for upper airway infections caused by viruses.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科","subitem_publisher_language":"ja"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article","subitem_radio_language":"en"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2434-4656","subitem_source_identifier_type":"EISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology Head and Neck Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine,  Department of Respiratory Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences"},{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology Head and Neck Surgery, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mami, Sato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tadaatsu, Imaizumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Jiangli, Ding","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kazuhiko, Seya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shogo, Kawaguchi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yusuke, Tanaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yasushi, Matsuzaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tomoh, Matsumiya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Atsushi, Matsubara","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-29"}],"filename":"Hirosaki Med J 74-1-4_117.pdf","filesize":[{"value":"490 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hirosaki.repo.nii.ac.jp/record/2000360/files/Hirosaki Med J 74-1-4_117.pdf"},"version_id":"1675e543-1058-4cbe-a327-a8d1398a489b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"STING","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RIG-I","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IFITM1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BEAS-2B","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Diamidobenzimidazole, an agonist of STING, induces the expression of retinoic acid-inducible gene-I and interferon-induced transmembrane protein 1 in BEAS-2B cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Diamidobenzimidazole, an agonist of STING, induces the expression of retinoic acid-inducible gene-I and interferon-induced transmembrane protein 1 in BEAS-2B cells","subitem_title_language":"en"}]},"item_type_id":"3","owner":"11","path":["1713851803406"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-04-29"},"publish_date":"2024-04-29","publish_status":"0","recid":"2000360","relation_version_is_last":true,"title":["Diamidobenzimidazole, an agonist of STING, induces the expression of retinoic acid-inducible gene-I and interferon-induced transmembrane protein 1 in BEAS-2B cells"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-11-20T00:30:15.337864+00:00"}