{"created":"2024-11-22T03:21:38.417972+00:00","id":2000652,"links":{},"metadata":{"_buckets":{"deposit":"b5349e10-95e8-4bbf-9656-c0f6489f6b8a"},"_deposit":{"created_by":11,"id":"2000652","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000652"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:02000652","sets":["557:561:1731912205403"]},"author_link":[],"control_number":"2000652","item_3_biblio_info_8":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-10-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"38","bibliographicPageStart":"31","bibliographicVolumeNumber":"75","bibliographic_titles":[{"bibliographic_title":"弘前医学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Hirosaki Medical Journal","bibliographic_titleLang":"en"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Backgrounds: Pulmonary arterial hypertension （PAH） is characterized by progressive remodeling of pulmonary arterioles, resulting in right heart failure. Although currently available therapeutic agents have improved clinical outcomes of PAH patients, the efficacy remains unsatisfactory. Src, originally identified as oncogene, participates in numerous signaling pathways regulating cell survival and proliferation. However, its role in the pathogenesis of PAH is largely unknown.\nMethods and Results: We treated wild-type mice with monocrotaline （MCT, 600 mg/kg） or vehicle （control） once a week for eight weeks to induce PAH, and Src-specific inhibitor PP1 （4 mg/kg） was injected three times per week concurrently with MCT. Right ventricular systolic pressure was significantly higher in MCT-treated mice than in control （60.1±8.1 vs. 20.6±1.1 mmHg, p<0.0001）, and PP1 attenuated the increase to 32.8±12.7 mmHg （p=0.0005）. The fibrotic area in the lung was greater in MCT-treated mice than in control （14.7±0.6 vs. 5.6±2.0%, p<0.0001）, and PP1 attenuated the increase to 8.9%±2.6%（ p=0.02）. In human pulmonary artery smooth muscle cells, endothelin increased mRNA expression of interleukin-6, and pretreatment with PP1 inhibited its increase.\nConclusions: Src inhibition may attenuate the progression of PAH induced by MCT through inhibiting inflammatory cytokine production. Our results may provide a novel clinical implication for PAH treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科","subitem_publisher_language":"ja"}]},"item_3_source_id_11":{"attribute_name":"item_3_source_id_11","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"item_3_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"2434-4656","subitem_source_identifier_type":"EISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naotake, Miura","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kenji, Hanada","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shun, Hirosawa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hitoshi, Umezaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yuki, Konno","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kazufumi, Kato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Toshihiro, Iwasaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirofumi, Tomita","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-11-22"}],"filename":"Hirosaki Med J 75-1_31.pdf","filesize":[{"value":"733 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hirosaki.repo.nii.ac.jp/record/2000652/files/Hirosaki Med J 75-1_31.pdf"},"version_id":"81bf1785-5b47-4289-8edf-2de2f1b5f541"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Pulmonary arterial hypertension","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Src","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary artery smooth muscle cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of Src ameliorates the progression of pulmonary arterial hypertension in experimental mouse model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of Src ameliorates the progression of pulmonary arterial hypertension in experimental mouse model","subitem_title_language":"en"}]},"item_type_id":"3","owner":"11","path":["1731912205403"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-22"},"publish_date":"2024-11-22","publish_status":"0","recid":"2000652","relation_version_is_last":true,"title":["Inhibition of Src ameliorates the progression of pulmonary arterial hypertension in experimental mouse model"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-11-29T01:46:22.204037+00:00"}