{"created":"2024-12-24T07:26:04.909148+00:00","id":2000716,"links":{},"metadata":{"_buckets":{"deposit":"ca75ca29-f834-418d-9052-57c0ed713bd2"},"_deposit":{"created_by":11,"id":"2000716","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000716"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:02000716","sets":["557:666:1733727873643"]},"author_link":[],"control_number":"2000716","item_1735019115310":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Candida albicans is an opportunistic pathogenic yeast that can survive in both normoxic and hypoxic environments. The involvement of C. albicans secretome on host biological processes has been demonstrated. However, the immunoregulatory function of C. albicans secretome released under hypoxic condition remains unclear. This study demonstrated the differences in cytokine responses and protein profiles between secretomes prepared under normoxic and hypoxic conditions. Furthermore, the immunoregulatory effects of heat shock protein SSA1(Ssa1), a protein candidate enriched in the hypoxic secretome, were investigated. Stimulation of mouse bone marrow-derived macrophages (BMMs) with Ssa1 resulted in the significant production of interleukin (IL)-10, IL-6, and tumor necrosis factor (TNF)-α as well as the significant expression of M2b macrophage markers (CD86, CD274 and tumor necrosis factor superfamily member 14), suggesting that C. albicans Ssa1 may promote macrophage polarization towards an M2b-like phenotype. Proteomic analysis of Ssa1- treated BMMs also revealed that Ssa1 reduced inflammation-related factors (IL-18-binding protein, IL-1 receptor antagonist protein, OX-2 membrane glycoprotein and cis-aconitate decarboxylase) and enhanced the proteins involved in anti-inflammatory response (CMRF35-like molecule 3 and macrophage colony-stimulating factor 1 receptor). Based on these results, we investigated the effect of Ssa1 on C. albicans infection and showed that Ssa1 inhibited the uptake of C. albicans by BMMs. Taken together, our results suggest that C. albicans alters its secretome, particularly by promoting the release of Ssa1, to modulate host immune response and survive under hypoxic conditions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1735020952570":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/cells13020127","subitem_relation_type_select":"DOI"}}]},"item_30001_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-01-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"127","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Cells","bibliographic_titleLang":"en"}]}]},"item_30001_creator2":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"滕, 巍","creatorNameLang":"ja"}]}]},"item_30001_date_granted20":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-09-30"}]},"item_30001_degree_grantor21":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_30001_degree_name19":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Author: Wei Teng, Phawinee Subsomwong, Kouji Narita, Akio Nakane, Krisana Asano","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Citation: Cells;13(2):127, 2024 Jan 10","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30001_dissertation_number18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2291号"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-24"}],"filename":"tdm_2291_teng.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://hirosaki.repo.nii.ac.jp/record/2000716/files/tdm_2291_teng.pdf"},"version_id":"fd26282b-6f42-4a0a-954e-5446b25d7486"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-24"}],"filename":"tdm_2291_teng_a1.pdf","filesize":[{"value":"164 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"内容要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000716/files/tdm_2291_teng_a1.pdf"},"version_id":"20acf0f3-2617-4b1e-b4a6-9b8239979774"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-24"}],"filename":"tdm_2291_teng_a2.pdf","filesize":[{"value":"180 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"審査要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000716/files/tdm_2291_teng_a2.pdf"},"version_id":"1b1d5e95-9893-4ee6-80cd-4e9714ba37a7"}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30001_resource_type11":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_30001_rights5":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).","subitem_rights_language":"en"}]},"item_30001_source_identifier16":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2073-4409","subitem_source_identifier_type":"EISSN"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Candida albicans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypoxia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"secretome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"heat shock protein SSA1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunomodulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Heat Shock Protein SSA1 Enriched in Hypoxic Secretome of Candida albicans Exerts an Immunomodulatory Effect via Regulating Macrophage Function","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"Heat Shock Protein SSA1 Enriched in Hypoxic Secretome of Candida albicans Exerts an Immunomodulatory Effect via Regulating Macrophage Function","item_type_id":"40034","owner":"11","path":["1733727873643"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-24"},"publish_date":"2024-12-24","publish_status":"0","recid":"2000716","relation_version_is_last":true,"title":["Heat Shock Protein SSA1 Enriched in Hypoxic Secretome of Candida albicans Exerts an Immunomodulatory Effect via Regulating Macrophage Function"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2025-01-28T05:07:44.669921+00:00"}