{"created":"2024-12-25T02:36:33.771964+00:00","id":2000717,"links":{},"metadata":{"_buckets":{"deposit":"37aea212-f0b1-40c2-b283-2ca28ac95c32"},"_deposit":{"created_by":11,"id":"2000717","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000717"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:02000717","sets":["557:666:1733727873643"]},"author_link":[],"control_number":"2000717","item_1735019115310":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Small nerve fibres located in the epidermis sense pain. Dysfunction of these fibres decreases the pain threshold known as small fibre neuropathy. Diabetes mellitus is accompanied by metabolic changes other than glucose, synergistically eliciting small fibre neuropathy. These findings suggest that various metabolic changes may be involved in small fibre neuropathy. Herein, we explored the correlation between pain sensation and changes in plasma metabolites in healthy Japanese subjects. The pain threshold evaluated from the intraepidermal electrical stimulation was used to quantify pain sensation in a total of 1021 individuals in the 2017 Iwaki Health Promotion Project. Participants with a pain threshold evaluated from the intraepidermal electrical stimulation index <0.20 mA were categorized into the pain threshold evaluated from the intraepidermal electrical stimulation index-low group (n = 751); otherwise, they were categorized into the pain threshold evaluated from the intraepidermal electrical stimulation indexhigh group (n = 270). Metabolome analysis of plasma was conducted using capillary electrophoresis time-of-flight mass spectrometry. The metabolite set enrichment analysis revealed that the metabolism of tryptophan was significantly correlated with the pain threshold evaluated from the intraepidermal electrical stimulation index in all participants (P < 0.05). The normalized level of tryptophan was significantly decreased in participants with a high pain threshold evaluated from the intraepidermal electrical stimulation index. In addition to univariate linear regression analyses, the correlation between tryptophan concentration and the pain threshold evaluated from the intraepidermal electrical stimulation index remained significant after adjustment for multiple factors (β = −0.07615, P < 0.05). These findings indicate that specific metabolic changes are involved in the deterioration of pain thresholds. Here, we show that abnormal tryptophan metabolism is significantly correlated with an elevated pain threshold evaluated from the intraepidermal electrical stimulation index in the Japanese population. This correlation provides insight into the pathology and clinical application of small fibre neuropathy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1735020952570":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/braincomms/fcae103","subitem_relation_type_select":"DOI"}}]},"item_30001_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"103","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Brain Communications","bibliographic_titleLang":"en"}]}]},"item_30001_creator2":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"櫛引, 英恵","creatorNameLang":"ja"}]}]},"item_30001_date_granted20":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-09-30"}]},"item_30001_degree_grantor21":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_30001_degree_name19":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Author: Hanae Kushibiki, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Takanori Sasaki, Saori Ogasawara, Kanichiro Wada, Shin Midorikawa, Masaki Ryuzaki, Zhenchao Wang, Takahiro Yamada, Keisuke Yamazaki, Takefusa Tarusawa, Taiyo Tanba, Tatsuya Mikami,  Atsushi Matsubara,  Yasuyuki Ishibashi, Kenichi Hakamada and Shigeyuki Nakaji","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Citation: Brain communications, 6(2):fcae103; 2024","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30001_dissertation_number18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2292号"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-25"}],"filename":"tdm_2292_kushibiki.pdf","filesize":[{"value":"995 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://hirosaki.repo.nii.ac.jp/record/2000717/files/tdm_2292_kushibiki.pdf"},"version_id":"9ea20cf2-8cf3-482e-8fca-1ee11f465176"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-25"}],"filename":"tdm_2292_kushibiki_a1.pdf","filesize":[{"value":"179 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"内容要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000717/files/tdm_2292_kushibiki_a1.pdf"},"version_id":"c1debca8-9388-4779-b69f-b3e25196f36d"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-25"}],"filename":"tdm_2292_kushibiki_a2.pdf","filesize":[{"value":"510 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"審査要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000717/files/tdm_2292_kushibiki_a2.pdf"},"version_id":"6b547e98-be52-4b77-87f6-f386c51c24e0"}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30001_publisher9":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_30001_resource_type11":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_30001_rights5":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.","subitem_rights_language":"en"}]},"item_30001_source_identifier16":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2632-1297","subitem_source_identifier_type":"EISSN"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetic polyneuropathy","subitem_subject_language":"en","subitem_subject_scheme":"UDC"},{"subitem_subject":"small fibre neuropathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metabolomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tryptophan","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tryptophan metabolism and small fibre neuropathy: a correlation study","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"Tryptophan metabolism and small fibre neuropathy: a correlation study","item_type_id":"40034","owner":"11","path":["1733727873643"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-25"},"publish_date":"2024-12-25","publish_status":"0","recid":"2000717","relation_version_is_last":true,"title":["Tryptophan metabolism and small fibre neuropathy: a correlation study"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2025-01-28T05:07:44.905091+00:00"}