{"created":"2024-12-25T06:47:46.917435+00:00","id":2000720,"links":{},"metadata":{"_buckets":{"deposit":"23b5d771-980d-4a0d-83b0-361788ada321"},"_deposit":{"created_by":11,"id":"2000720","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000720"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:02000720","sets":["557:666:1733727873643"]},"author_link":[],"item_1735019115310":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Backgrounds: Pulmonary arterial hypertension （PAH） is characterized by progressive remodeling of pulmonary arterioles, resulting in right heart failure. Although currently available therapeutic agents have improved clinical outcomes of PAH patients, the efficacy remains unsatisfactory. Src, originally identified as oncogene, participates in numerous signaling pathways regulating cell survival and proliferation. However, its role in the pathogenesis of PAH is largely unknown.\nMethods and Results: We treated wild-type mice with monocrotaline （MCT, 600 mg/kg） or vehicle （control） once a week for eight weeks to induce PAH, and Src-specific inhibitor PP1 （4 mg/kg） was injected three times per week concurrently with MCT. Right ventricular systolic pressure was significantly higher in MCT-treated mice than in control （60.1±8.1 vs. 20.6±1.1 mmHg, p<0.0001）, and PP1 attenuated the increase to 32.8±12.7 mmHg （p=0.0005）. The fibrotic area in the lung was greater in MCT-treated mice than in control （14.7±0.6 vs. 5.6±2.0%, p<0.0001）, and PP1 attenuated the increase to 8.9%±2.6%（ p=0.02）. In human pulmonary artery smooth muscle cells, endothelin\nincreased mRNA expression of interleukin-6, and pretreatment with PP1 inhibited its increase.\nConclusions: Src inhibition may attenuate the progression of PAH induced by MCT through inhibiting inflammatory cytokine production. Our results may provide a novel clinical implication for PAH treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_30001_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-10-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"38","bibliographicPageStart":"31","bibliographicVolumeNumber":"75","bibliographic_titles":[{"bibliographic_title":"The Hirosaki Medical Journal","bibliographic_titleLang":"en"}]}]},"item_30001_creator2":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三浦, 尚武","creatorNameLang":"ja"}]}]},"item_30001_date_granted20":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-09-30"}]},"item_30001_degree_grantor21":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_30001_degree_name19":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Author: Naotake Miura, Kenji Hanada, Shun Hirosawa, Hitoshi Umezaki, Yuki Konno, Kazufumi Kato, Toshihiro Iwasaki, and Hirofumi Tomita","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Citation: The Hirosaki Medical Journal Vol75, No.1, 31-38, 2024","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30001_dissertation_number18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2295号"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-25"}],"filename":"tdm_2295_miura.pdf","filesize":[{"value":"667 KB"}],"format":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://hirosaki.repo.nii.ac.jp/record/2000720/files/tdm_2295_miura.pdf"},"version_id":"d0efa859-5d7d-4b16-a9a2-e2fb76ebb654"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-25"}],"filename":"tdm_2295_miura_a1.pdf","filesize":[{"value":"158 KB"}],"format":"application/pdf","url":{"label":"内容要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000720/files/tdm_2295_miura_a1.pdf"},"version_id":"dc2dcc63-a88c-410b-9075-4b70d440a9e9"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-25"}],"filename":"tdm_2295_miura_a2.pdf","filesize":[{"value":"161 KB"}],"format":"application/pdf","url":{"label":"審査要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000720/files/tdm_2295_miura_a2.pdf"},"version_id":"349eea5d-9de2-4d8d-bc69-1ff44a212e70"}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30001_publisher9":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学出版会","subitem_publisher_language":"ja"}]},"item_30001_resource_type11":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_30001_source_identifier16":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2434-4656","subitem_source_identifier_type":"EISSN"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Pulmonary arterial hypertension","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Src","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary artery smooth muscle cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of Src ameliorates the progression of pulmonary arterial hypertension in experimental mouse model","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"Inhibition of Src ameliorates the progression of pulmonary arterial hypertension in experimental mouse model","item_type_id":"40034","owner":"11","path":["1733727873643"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-25"},"publish_date":"2024-12-25","publish_status":"0","recid":"2000720","relation_version_is_last":true,"title":["Inhibition of Src ameliorates the progression of pulmonary arterial hypertension in experimental mouse model"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2025-01-28T05:07:47.142702+00:00"}