| Item type |
リポジトリ登録用アイテムタイプ（シンプル）(1) |
| 公開日 |
2025-03-25 |
| タイトル |
|
|
タイトル |
Effect of glycosaminoglycan structure on all-trans-retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neural differentiation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glycosaminoglycan |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chondroitin sulfate |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Heparin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hyaluronan |
| 資源タイプ |
|
|
資源タイプ識別子（シンプル） |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ（シンプル） |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
Ikuko, Kakizaki
Takayasu, Kobayashi
Shinri, Tamura
Hiroshi, Akagi
Keiichi, Takagaki
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Glycosaminoglycan polysaccharides are components of animal extracellular matrices and regulate cell functions based on their various sulfation and epimerization pattern structures. The present study aimed to find glycosaminoglycan structures to promote neural differentiation. We investigated the effect of exogenous glycosaminoglycans with well-defined structures on the all-trans-retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells, which is an ideal model culture system for studying neural differentiation. We found that chondroitin sulfate E and heparin, but not any other glycosaminoglycans, upregulated the expressions of neural specific markers but not a grail specific marker. Chondroitin sulfate E was suggested to function during spheroid formation, however, equimolar concentration of its oligosaccharide did not show promotive effect on the neural differentiation. Another finding was that hyaluronan oligosaccharide mixture markedly downregulated the expressions of a myelin specific marker. These findings suggested that the specific sulfation pattern and/or chain length of exogenous added glycosaminoglycan is important to regulate neural differentiation and myelination. |
|
言語 |
en |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
巻 570,
p. 169-174,
発行日 2021-09-17
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
0006-291X |
| item_1735020952570 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.bbrc.2021.07.012 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2021 Elsevier Inc. All rights reserved. |
| 出版タイプ |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.sciencedirect.com/science/article/pii/S0006291X21010378?via%3Dihub |
