{"created":"2025-06-17T01:15:13.602036+00:00","id":2000933,"links":{},"metadata":{"_buckets":{"deposit":"5c8d0473-7af8-4873-964b-1f0fbd0b3fc8"},"_deposit":{"created_by":11,"id":"2000933","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000933"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:02000933","sets":["557:666:1747629202301"]},"author_link":[],"control_number":"2000933","item_1735019115310":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: We aimed to create a rat model of drug-induced parkinsonism and tardive dyskinesia by chronic administration of haloperidol and examine the expression of direct and indirect pathway markers in the striatum of the model rats.\nMethods: We treated 21 rats, 14 with haloperidol decanoate and 7 with placebo. The number of vacuous chewing movements per 2 min was counted, and haloperidol-treated rats were classified into two groups: mild and severe tardive dyskinesia. Other behavioral analyses were also conducted. After a 6-month treatment period, rat brains were removed, and protein expression was evaluated by Western blotting.\nResults: All haloperidol-treated rats exhibited vacuous chewing movements. The frequency of exploratory behavior and rotarod test performance was lower in the mild and severe tardive dyskinesia groups. The number of vacuous chewing movements and frequency of exploratory behavior were positively correlated in haloperidol-treated rats. The expression of dynorphin, a direct pathway marker, decreased in the severe tardive dyskinesia group. The expression of enkephalin, an indirect pathway marker, decreased both in the mild and severe tardive dyskinesia groups. The expression of dopamine D1 and D2 receptors also decreased with haloperidol treatment.\nConclusion: Both direct and indirect pathways are involved in haloperidol-induced movement disorders.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1735020952570":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/npr2.12524","subitem_relation_type_select":"DOI"}}]},"item_30001_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Neuropsychopharmacology Reports","bibliographic_titleLang":"en"}]}]},"item_30001_creator2":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAlternatives":[{"creatorAlternative":"Iku, Kinoshita","creatorAlternativeLang":"en"}],"creatorNames":[{"creatorName":"木下, 郁","creatorNameLang":"ja"}]}]},"item_30001_date_granted20":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2025-03-24"}]},"item_30001_degree_grantor21":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"弘前大学"}]}]},"item_30001_degree_name19":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Author(s): Iku Kinoshita, Haruo Nishijima, Takashi Nakamura, Tomoya Kon, Shuji Shimoyama, Hiroki Hikichi, Chieko Suzuki, Masahiko Tomiyama\nNeuropsychopharmacology Reports, 2025; 45:e12524","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30001_dissertation_number18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2317号"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-17"}],"filename":"tdm_2317_kinoshita.pdf","filesize":[{"value":"1 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://hirosaki.repo.nii.ac.jp/record/2000933/files/tdm_2317_kinoshita.pdf"},"version_id":"9f7c265a-7fd7-4302-a538-5c113c89b8bb"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-17"}],"filename":"tdm_2317_kinoshita_a1.pdf","filesize":[{"value":"167 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"内容要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000933/files/tdm_2317_kinoshita_a1.pdf"},"version_id":"289671a4-65a2-47a1-9457-3e68737e1b49"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-17"}],"filename":"tdm_2317_kinoshita_a2.pdf","filesize":[{"value":"212 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"審査要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000933/files/tdm_2317_kinoshita_a2.pdf"},"version_id":"85f4c99f-b126-4bc2-ab8c-b79f4fb08760"}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30001_publisher9":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_30001_resource_type11":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_30001_rights5":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"},{"subitem_rights":"© 2025 The Author(s). Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology","subitem_rights_language":"en"}]},"item_30001_source_identifier16":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2574-173X","subitem_source_identifier_type":"EISSN"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"direct pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dopamine D1 receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dopamine D2 receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dynorphin | enkephalin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"indirect pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vacuous chewing movement","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Co-Expression of Tardive Dyskinesia and Drug-Induced Parkinsonism in Rats Chronically Treated With Haloperidol","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"Co-Expression of Tardive Dyskinesia and Drug-Induced Parkinsonism in Rats Chronically Treated With Haloperidol","item_type_id":"40034","owner":"11","path":["1747629202301"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-06-17"},"publish_date":"2025-06-17","publish_status":"0","recid":"2000933","relation_version_is_last":true,"title":["Co-Expression of Tardive Dyskinesia and Drug-Induced Parkinsonism in Rats Chronically Treated With Haloperidol"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2025-06-30T05:15:15.251317+00:00"}