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The potential effectiveness of tolvaptan in critically ill patients including cardiac and noncardiac populations: a retrospective observational study
http://hdl.handle.net/10129/0002000942
http://hdl.handle.net/10129/000200094281c0356d-8395-43e8-b040-9a566c36fb23
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内容要旨 (294 KB)
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審査要旨 (125 KB)
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| アイテムタイプ | リポジトリ登録用アイテムタイプ（シンプル）(1) | |||||||
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| 公開日 | 2025-06-19 | |||||||
| タイトル | ||||||||
| タイトル | The potential effectiveness of tolvaptan in critically ill patients including cardiac and noncardiac populations: a retrospective observational study | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | critically ill patient | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | cardiac disease | |||||||
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| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | diuretic agent | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | multivariable logistic regression model | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | noncardiac disease | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | tolvaptan | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
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| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
山﨑, 佑眞
× 山﨑, 佑眞
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Purpose: We investigated the potential diuretic effectiveness of the selective arginine vasopressin 2 receptor antagonist tolvaptan in critically ill patients including cardiac and noncardiac populations. Methods: This was a single-center retrospective observational study. We analyzed the data of our hospital's critically ill adult patients (n=473) including noncardiac as well as cardiac populations who had an ICU stay ≥4 days in 2019–2020 and who did not undergo renal transplantation or permanent renal replacement therapy before their ICU admission. Adjusting for several confounders (the patients' disease severity, comorbidities including cardiac disease, and diuretics used), we estimated the predictors for the patients whose daily urine volume had increased by up to twofold or more compared to the minimal value (the primary endpoint) by applying a multivariable logistic regression model. We also investigated tolvaptan's effect on time-course changes in the serum creatine (sCr) level (the secondary endpoint) by using a generalized estimating equation model. Results: Tolvaptan use was significantly correlated with increased urine volume (odds ratio [OR] 1.86, 95%CI: 1.13–3.06, p=0.015) but was not significantly associated with time-course changes in the sCr level: beta estimator [95%CI], 0.07 [−0.01 to 0.15], p=0.08. Conclusion: Tolvaptan independently increased the urine volume, apparently without worsening the renal function in critically ill patients including cardiac and noncardiac populations. |
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| 言語 | en | |||||||
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| 内容記述タイプ | Other | |||||||
| 内容記述 | Yamazaki, Y., Niwa, H., Ishiyama, E. et al. The potential effectiveness of tolvaptan in critically ill patients including cardiac and noncardiac populations: a retrospective observational study. Naunyn-Schmiedeberg's Arch Pharmacol 398, 5427–5436 (2025). https://doi.org/10.1007/s00210-024-03618-2 | |||||||
| 言語 | en | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1007/s00210-024-03618-2 | |||||||
| 権利情報 | ||||||||
| 権利情報 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00210-024-03618-2 | |||||||
| 言語 | en | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | NA | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||
| 出版者 | ||||||||
| 出版者 | Springer Nature | |||||||
| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 言語 | ja | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関名 | 弘前大学 | |||||||
| 言語 | ja | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2025-03-24 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第2325号 | |||||||
