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Association between NF-E2-related factor 2 polymorphism and age-related hearing loss in the general Japanese population from the Iwaki health promotion project
http://hdl.handle.net/10129/0002000945
http://hdl.handle.net/10129/0002000945e34a06cc-c256-461b-a97f-bf4b43edbdc3
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本文 (749 KB)
Download is available from 2025/12/6.
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内容要旨 (258 KB)
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審査要旨 (209 KB)
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| Item type | リポジトリ登録用アイテムタイプ（シンプル）(1) | |||||||
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| 公開日 | 2025-06-20 | |||||||
| タイトル | ||||||||
| タイトル | Association between NF-E2-related factor 2 polymorphism and age-related hearing loss in the general Japanese population from the Iwaki health promotion project | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | NRF2 SNP-617 | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | age-related hearing loss | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | reactive oxygen species | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | general population | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Iwaki Health Promotion Project | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | embargoed access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||
| 著者 |
葛西, 崇
× 葛西, 崇
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background: Single-nucleotide polymorphisms (SNPs) of the NF-E2-related factor 2 (NRF2) gene might be associated with several diseases. In the animal models, NRF2 has been reported to be associated with the age-related hearing loss (ARHL). However, the effect of NRF2 SNPs on ARHL in the general population has not been reported. Objectives: This study aimed to evaluate the effect of NRF2 SNP-617 on ARHL in the general Japanese population. Methods: This study included participants from the Iwaki Health Promotion Project. The genotypes of NRF2 SNP-617 were determined via whole-genome sequencing, and the hearing level of the CC homozygote+CA heterozygote carrier group was compared with that of the AA homozygote carrier group. Results: Among the 306 CC+CA and 31 AA group male subjects, 22 (7.2%) and six (19.4%), respectively, had hearing loss, with a significant difference. Multiple logistic regression analysis showed that the risk of hearing loss in the male subjects was significantly higher in the AA group than that in the CC+CA group (p=0.031, odds ratio=3.437, 95% confidence interval=1.116–10.580). Conclusion: The genotypes of NRF2 SNP-617 AA carriers were significantly associated with the development of ARHL among the males aged 30–59 years. |
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| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Author: Takashi Kasai, Akira Sasaki, Shuya Kasai, Shiori Miura, Shinichi Goto, Ryoko Yotsuyanagi, Tatsuya Mikami, Yoshinori Tamada, Ken Itoh, Atsushi Matsubara Acta Oto-Laryngologica. 2025 Jan;145(1):36-42. doi: 10.1080/00016489.2024.2435459. Epub 2024 Dec 6. http://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
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| 言語 | en | |||||||
| 書誌情報 |
en : Acta Oto-laryngologica 巻 145, 号 1, p. 36-42, 発行日 2024-12-06 |
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| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1651-2251 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1080/00016489.2024.2435459 | |||||||
| 権利情報 | ||||||||
| 言語 | en | |||||||
| 権利情報 | This is an original manuscript of an article published by Taylor & Francis in Acta Oto-Laryngologica on 06 Dec 2024, available at: https://doi.org/10.1080/00016489.2024.2435459. | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | NA | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||
| 出版者 | ||||||||
| 出版者 | Taylor & Francis | |||||||
| 言語 | en | |||||||
| 学位名 | ||||||||
| 言語 | ja | |||||||
| 学位名 | 博士（医学） | |||||||
| 学位授与機関 | ||||||||
| 言語 | ja | |||||||
| 学位授与機関名 | 弘前大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2025-03-24 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第2328号 | |||||||
