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アイテム
Chondroitin sulfate chain of urinary trypsin inhibitor plays an important role in anti-inflammatory effects
http://hdl.handle.net/10129/0002000947
http://hdl.handle.net/10129/00020009479ed29bc0-e793-4305-9047-398f5feebd43
| 名前 / ファイル | ライセンス | アクション |
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審査要旨 (263 KB)
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| Item type | リポジトリ登録用アイテムタイプ（シンプル）(1) | |||||||
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| 公開日 | 2025-06-23 | |||||||
| タイトル | ||||||||
| タイトル | Chondroitin sulfate chain of urinary trypsin inhibitor plays an important role in anti-inflammatory effects | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | chondroitin sulfate | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | inflammation | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | urinary trypsin inhibitor | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
小玉, 都萌
× 小玉, 都萌
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Aim: This study aimed to investigate the role of the chondroitin sulfate (ChS) chain in the anti-inflammatory effect of urinary trypsin inhibitors (UTIs), identify ChS structures that enhance the anti-inflammatory activity of UTIs, and develop a more effective treatment for preterm birth. Methods: ChS chain-remodeled UTIs were prepared by hydrolysis and/or transglycosylation reaction of testicular hyaluronidase. Uterine cervical fibroblasts were treated with native and ChS-remodeled UTIs and incubated with lipopolysaccharide to induce inflammation. To assess anti-inflammatory effects, interleukin-8 (IL-8) concentrations in the culture supernatants were measured by enzyme-linked immunosorbent assay. Results: Compared with controls without UTIs, Ch6S-transferred UTI at the nonreducing terminal significantly suppressed IL-8 release. Other UTIs showed limited suppression. Conclusion: The Ch6S chain at the nonreducing terminus of UTI enhances its antiinflammatory effect. This finding could lead to the development of innovative treatments for preterm birth. |
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| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Author(s): Tomoe Kodama, Ikuko Kakizaki, Kanji Tanaka, Seigo Tanaka, Asami Ito-Fukuyama, Shinichiro Suto, Saki Kurotaki, Ryuto Tsushima, Maki Sato, Ryoki Takahashi, Yoshihito Yokoyama 掲載誌： 巻号頁： Volume 13 Issue 1 Pages 10-16 Published: February 28, 2025 Released on J-STAGE: February 28, 2025 Advance online publication: January 21, 2025 DOI: https://doi.org/10.14390/jsshp.HRP2024-016 Hypertension Research in Pregnancy © 2025 Japan Society for the Study of Hypertension in Pregnancy |
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| 言語 | ja | |||||||
| 書誌情報 |
en : Hypertension Research in Pregnancy（日本妊娠高血圧学会） 巻 13, 号 1, p. 10-16, 発行日 2025-02-28 |
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| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2187-9931 | |||||||
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| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 2187-5987 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.14390/jsshp.HRP2024-016 | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | NA | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||
| 出版者 | ||||||||
| 出版者 | 一般社団法人 日本妊娠高血圧学会 | |||||||
| 言語 | ja | |||||||
| 学位名 | ||||||||
| 言語 | ja | |||||||
| 学位名 | 博士（医学） | |||||||
| 学位授与機関 | ||||||||
| 言語 | ja | |||||||
| 学位授与機関名 | 弘前大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2025-03-24 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第2330号 | |||||||
