{"created":"2025-06-23T04:24:24.342534+00:00","id":2000949,"links":{},"metadata":{"_buckets":{"deposit":"98f85448-00ec-4ae9-9833-c944513a6194"},"_deposit":{"created_by":11,"id":"2000949","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000949"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:02000949","sets":["557:1754614239215:666:1747629202301"]},"author_link":[],"control_number":"2000949","item_1735019115310":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives\nPrevious studies have shown possible choroid plexus (CP) dysfunction in Alzheimer’s disease (AD) and highlighted CP enlargement on magnetic resonance imaging (MRI) as a predictive factor of AD. However, few studies have assessed the relationship between CP volume (CPV) and mild cognitive impairment (MCI). In this large elderly population study, we investigated the changes in CPV in patients with MCI using MRI above 65 years.\n\nMethods\nThis cross-sectional study included 2144 participants (median age, 69 years; 60.9% females) who underwent 3T MRI; they were grouped as 218 MCI participants and 1904 cognitively healthy controls. The total intracranial volume (ICV), total brain volume (TBV), CPV, hippocampal volume (HV), and lateral ventricle volume (LVV) were calculated.\n\nResults\nCPV/ICV was a significant independent predictor of MCI (p < 0.01) after adjusting for potential confounders (age, sex, hypertension, hyperlipidemia, diabetes, and education level). The CPV/ICV ratio was also a significant independent predictor of MCI after adjusting for the TBV/ICV ratio (p = 0.022) or HV/ICV ratio (p = 0.017), in addition to potential confounders. The CPV was significantly correlated with the LVV (r = 0.97, p < 0.01).\n\nConclusion\nWe identified a relationship between CPV and MCI, which could not be explained by the degree of brain atrophy. Our results support CP dysfunction in MCI.\n\nClinical relevance statement\nChoroid plexus volume measurement may serve as a valuable imaging biomarker for diagnosing and monitoring mild cognitive impairment. The enlargement of the choroid plexus, independent of brain atrophy, suggests its potential role in mild cognitive impairment pathology.\n\nKey Points\n• The study examines choroid plexus volume in relation to cognitive decline in elderly.\n• Enlarged choroid plexus volume independently indicates mild cognitive impairment presence.\n• Choroid plexus volume could be a specific biomarker for early mild cognitive impairment diagnosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1735020952570":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00330-023-10572-9","subitem_relation_type_select":"DOI"}}]},"item_1756857892097":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_30001_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-01-15","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5304","bibliographicPageStart":"5297","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"European Radiology","bibliographic_titleLang":"en"}]}]},"item_30001_creator2":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梅村, 芳史","creatorNameLang":"en"}]}]},"item_30001_date_granted20":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2025-03-24"}]},"item_30001_degree_grantor21":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"弘前大学"}]}]},"item_30001_degree_name19":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Author(s): Yoshihito Umemura, Keita Watanabe, Sera Kasai, Satoru Ide, Yuka Ishimoto, Miho Sasaki, Haruka Nagaya, Soichiro Tatsuo, Tatsuya Mikami, Yoshinori Tamada, Masahiko Tomiyama, Shingo Kakeda\n\nThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:https://doi.org/10.1007/s00330-023-10572-9","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30001_dissertation_number18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2332号"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-23"}],"filename":"tdm_2332_umemura_a1.pdf","filesize":[{"value":"202 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"内容要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000949/files/tdm_2332_umemura_a1.pdf"},"version_id":"5e97bb54-8a0a-44eb-8154-3961543801a8"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-23"}],"filename":"tdm_2332_umemura_a2.pdf","filesize":[{"value":"107 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"審査要旨","objectType":"abstract","url":"https://hirosaki.repo.nii.ac.jp/record/2000949/files/tdm_2332_umemura_a2.pdf"},"version_id":"5dcc7641-cb5a-415b-b502-34c303bb4c1f"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-23"}],"filename":"tdm_2332_umemura1.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://hirosaki.repo.nii.ac.jp/record/2000949/files/tdm_2332_umemura1.pdf"},"version_id":"74553d25-2b7b-434b-ab29-fc2072ff4bb2"}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30001_publisher9":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_30001_source_identifier16":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1432-1084","subitem_source_identifier_type":"EISSN"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Mild cognitive impairment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Choroid plexus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hippocampal volume","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Choroid plexus enlargement in mild cognitive impairment on MRI: a large cohort study","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_title":"Choroid plexus enlargement in mild cognitive impairment on MRI: a large cohort study","item_type_id":"40034","owner":"11","path":["1747629202301"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-06-23"},"publish_date":"2025-06-23","publish_status":"0","recid":"2000949","relation_version_is_last":true,"title":["Choroid plexus enlargement in mild cognitive impairment on MRI: a large cohort study"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2025-09-19T02:54:53.235918+00:00"}