| Item type |
リポジトリ登録用アイテムタイプ（シンプル）(1) |
| 公開日 |
2025-10-14 |
| タイトル |
|
|
タイトル |
An epidemiological study on the factors including genetic polymorphism influencing ALT >30 U/L and liver fibrosis progression in metabolic dysfunction-associated steatotic liver disease among the general population |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cardiovascular metabolic risk factors |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lifestyle |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
liver fibrosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
metabolic dysfunction-associated steatotic liver disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
single-nucleotide polymorphisms |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Sato, Satoshi
Iino, Chikara
Sasada, Takafumi
Soma, Go
Furusawa, Keisuke
Yoshida, Kenta
Sawada, Kaori
Mikami, Tatsuya
Fukuda, Shinsaku
Nakaji, Shigeyuki
Sakuraba, Hirotake
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Background and Aim
Identifying the factors contributing to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), a lifestyle-related disease, is crucial for preventing future liver-related deaths. This study aimed to epidemiologically investigate factors, including single-nucleotide polymorphisms (SNPs) associated with alanine aminotransferase (ALT) levels >30 U/L and potential risk factors for liver fibrosis, in a general population cohort of patients with MASLD.
Methods
Among 1059 participants in the health checkup project, 228 who were diagnosed with MASLD were analyzed. Liver fat content and stiffness were measured using FibroScan, and 13 SNPs associated with non-alcoholic fatty liver disease (NAFLD) were measured in addition to other clinical parameters.
Results
In the multivariate analysis, male sex, younger age, and high triglyceride levels were significant risk factors for ALT levels >30 U/L (P-value < 0.05). Furthermore, among the 13 SNPs measured, only the GG genotypes of patatin-like phospholipase domain-containing 3 gene (PNPLA3) rs738409 and rs2896019 were significant risk factors for ALT levels >30 U/L (P-value 0.004 and 0.007). The GG genotypes of PNPLA3 rs738409 and rs2896019 had higher FibroScan-aspartate aminotransferase (FAST) and APRI scores than the CC + CG and TT + TG genotypes (P-value < 0.05). In addition, multivariate analysis revealed that the GG genotypes of rs738409 and rs2896019 were significant risk factors independent of cardiovascular metabolic risk for patients with MASLD (P-value 0.038 and 0.021).
Conclusion
An individualized treatment approach is warranted for patients with MASLD due to the influence of various factors on its progression, including genetic factors and lifestyle diseases. |
|
言語 |
en |
| 書誌情報 |
en : JGH Open
巻 8,
号 12,
p. e70043,
発行日 2024-12
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2397-9070 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1002/jgh3.70043 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2024 The Author(s). JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
JGH_8 (2024) e70043.pdf (422 KB)
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