| アイテムタイプ |
リポジトリ登録用アイテムタイプ（シンプル）(1) |
| 公開日 |
2025-10-14 |
| タイトル |
|
|
タイトル |
Epidemiological Study on the Interaction between the PNPLA3 (rs738409) and Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
MASLD |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SNPs |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PNPLA3 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gut microbiota |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Sato, Satoshi
Iino, Chikara
Sasada, Takafumi
Soma, Go
Furusawa, Keisuke
Yoshida, Kenta
Sawada, Kaori
Mikami, Tatsuya
Nakaji, Shigeyuki
Sakuraba, Hirotake
Fukuda, Shinsaku
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Many factors are associated with the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD); however, genetics and gut microbiota are representative factors. Recent studies have highlighted the link between host genes and the gut microbiota. Although there have been many studies on the separate effects of single nucleotide polymorphisms (SNPs) and gut bacteria on MASLD, few epidemiological studies have examined how SNPs and gut bacteria interact in the development and progression of MASLD. This study aimed to investigate the association between PNPLA3 rs738409, a representative MASLD-related SNP, and gut bacteria in MASLD using a cross-sectional study of the general population. The 526 participants (318 normal and 208 MASLD groups) were grouped into the PNPLA3 rs738409 SNP, CC, CG, and GG genotypes, and the differences in the gut microbiota were investigated in each group. The PNPLA3 rs738409 CC and CG genotypes were associated with decreased Blautia and Ruminococcaceae in the MASLD group. They were negatively correlated with controlled attenuation parameter levels, body mass index, serum blood glucose, and triglycerides. In contrast, there was no association between the normal and MASLD groups and the gut bacteria in the PNPLA3 rs738409, the GG genotype group. This finding implies that dietary interventions and probiotics may be more effective in preventing and treating MASLD in individuals with the PNPLA3 rs738409 CC and CG genotypes. In contrast, their efficacy may be limited in those with the GG genotype. |
|
言語 |
en |
| 書誌情報 |
en : Genes
巻 15,
号 9,
p. 1117
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2073-4425 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/genes15091172 |
| 権利情報 |
|
|
権利情報 |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
Genes 2024, 15, 1172..pdf (2.5 MB)
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