| アイテムタイプ |
リポジトリ登録用アイテムタイプ（シンプル）(1) |
| 公開日 |
2025-10-14 |
| タイトル |
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タイトル |
A 4-year cohort study of the effects of PNPLA3 rs738409 genotypes on liver fat and fibrosis and gut microbiota in a non-fatty liver population |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Liver fat |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Liver fibrosis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Patatin-like phospholipase domain-containing 3 (PNPLA3) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Gut microbiota |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cohort study |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Sato, Satoshi
Iino, Chikara
Sasada, Takafumi
Furusawa, Keisuke
Yoshida, Kenta
Sawada, Kaori
Mikami, Tatsuya
Fukuda, Shinsaku
Nakaji, Shigeyuki
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Many factors are associated with the development and progression of liver fat and fibrosis; however, genetics and the gut microbiota are representative factors. Moreover, recent studies have indicated a link between host genes and the gut microbiota. This study investigated the effect of patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 (C > G), which has been reported to be most involved in the onset and progression of fatty liver, on liver fat and fibrosis in a cohort study related to gut microbiota in a non-fatty liver population.
Methods: This cohort study included 214 participants from the health check-up project in 2018 and 2022 who had non-fatty liver with controlled attenuation parameter (CAP) values <248 dB/m by FibroScan and were non-drinkers. Changes in CAP values and liver stiffness measurement (LSM), liver-related items, and gut microbiota from 2018 to 2022 were investigated separately for PNPLA3 rs738409 CC, CG, and GG genotypes.
Results: Baseline values showed no difference among the PNPLA3 rs738409 genotypes for any of the measurement items. From 2018 to 2022, the PNPLA3 rs738409 CG and GG genotype groups showed a significant increase in CAP and body mass index; no significant change was observed in the CC genotype group. LSM increased in all genotypes, but the rate of increase was highest in the GG genotype, followed by the CG and CC genotypes. Fasting blood glucose levels increased in all genotypes; however, HOMA-IR (Homeostasis Model Assessment of Insulin Resistance) increased significantly only in the GG genotype. HDL (high-density lipoprotein) and LDL (low-density lipoprotein) cholesterol levels significantly increased in all genotypes, whereas triglycerides did not show any significant changes in any genotype. As for the gut microbiota, the relative abundance of Feacalibacterium in the PNPLA3 rs738409 GG genotype decreased by 2% over 4 years, more than 2-fold compared to CC and GG genotypes. Blautia increased significantly in the CC group.
Conclusion: The results suggest that PNPLA3 G-allele carriers of non-fatty liver develop liver fat and fibrosis due to not only obesity and insulin resistance but also the deterioration of gut microbiota, which may require a relatively long course of time, even years. |
|
言語 |
en |
| 書誌情報 |
en : Environmental Health and Preventive Medicine
巻 30,
p. 17,
発行日 2025
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| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1347-4715 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1265/ehpm.24-00365 |
| 権利情報 |
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|
権利情報 |
© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. http://creativecommons.org/licenses/by/4.0/ |
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言語 |
en |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
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出版者 |
日本衛生学会 |
|
言語 |
ja |
EHPM_30(17)_24-00365 - (2025) .pdf (1.4 MB)
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