| Item type |
リポジトリ登録用アイテムタイプ（シンプル）(1) |
| 公開日 |
2025-10-14 |
| タイトル |
|
|
タイトル |
Effect of Oral Microbiota Composition on Metabolic Dysfunction-Associated Steatotic Liver Disease in the General Population |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
metabolic dysfunction-associated steatotic liver disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oral microbiota |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
general population |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Sato, Satoshi
Iino, Chikara
Furusawa, Keisuke
Yoshida, Kenta
Chinda, Daisuke
Sawada, Kaori
Mikami, Tatsuya
Nakaji, Shigeyuki
Fukuda, Shinsaku
Sakuraba, Hirotake
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background/Objective: This study investigated the relationship between the composition of oral microbiota and metabolic dysfunction-associated steatotic liver disease (MASLD) in the general population.
Methods: In total, 712 participants in a health check-up project were divided into four oral microbiota patterns by principal component analysis and cluster analysis; they were included in Neisseria, Streptococcus, Fusobacterium, and Veillonella groups. The Neisseria group had the largest number of patients and was used as a reference group to compare the incidence of MASLD and cardiometabolic criteria with the other groups.
Results: In a multivariate analysis, the Veillonella group was a risk factor for MASLD independent of cardiometabolic criteria compared with the Neisseria group. The correlation between oral bacterial species and MASLD-related items showed that Neisseria was negatively correlated with controlled attenuation parameters, body mass index, waist circumference, hemoglobin A1c, alanine aminotransferase, and fatty liver index. Veillonella showed a positive correlation with controlled attenuation parameters, waist circumference, body mass index, blood pressure, triglycerides, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, and fatty liver index, and a negative correlation with high-density lipoprotein cholesterol. In contrast, the Streptococcus and Fusobacterium groups were not clearly associated with MASLD.
Conclusions: Maintaining oral hygiene and preventing periodontitis may contribute to preventing MASLD and extending a healthy lifespan. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Clinical Medicine
巻 14,
号 6,
p. 2013,
発行日 2025-03
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2077-0383 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/jcm14062013 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
J. Clin. Med. 2025, 14, 2013.pdf (723 KB)
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