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Involvement of Megasphaera in the Oral Microbiome and Dyslipidemia Onset: Evidence from a Community-Based Study in Japan
http://hdl.handle.net/10129/0002001852
http://hdl.handle.net/10129/0002001852098f4ca9-56fb-4866-8c04-cec57780041d
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本文 (1.2 MB)
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内容要旨 (192 KB)
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審査要旨 (148 KB)
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| アイテムタイプ | リポジトリ登録用アイテムタイプ（シンプル）(1) | |||||||||
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| 公開日 | 2025-11-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Involvement of Megasphaera in the Oral Microbiome and Dyslipidemia Onset: Evidence from a Community-Based Study in Japan | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Dyslipidemia | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Oral microbiome | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | LEfSe | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Periodontitis | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Megasphaera | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Porphyromonas | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | embargoed access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||
| 著者 |
高木, 康貴
× 高木, 康貴
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Dyslipidemia is a major risk factor for cardiovascular diseases and is influenced by genetic and environmental factors, including diet. Emerging research suggests a link between the gut microbiome and metabolic disorders. While the connection between the gut microbiota and dyslipidemia is well documented, the specific relationship between oral bacteria and dyslipidemia has not been thoroughly investigated. This study aimed to identify oral bacterial species associated with dyslipidemia in a community-based Japanese population. We conducted a metagenomic analysis on tongue coating samples from 763 participants in the Iwaki Health Promotion Project, which were collected during health checkups in 2017 and 2019. Dyslipidemia was diagnosed using standard lipid level criteria. The oral microbiome was analyzed via 16S rDNA amplicon sequencing. Statistical analyses included multiple regression and β diversity assessments. Our analysis revealed that the abundances of several bacterial genera, including Veillonella, Atopobium, Stomatobaculum, Tanneralla, and Megasphaera, are significantly associated with dyslipidemia. A higher relative abundance of Megasphaera was specifically observed in individuals with dyslipidemia. Moreover, Megasphaera abundance was closely associated with the onset of dyslipidemia (p = 0.038, odds ratio: 1.005, 95% confidence interval: 1.000–1.009), suggesting its role in metabolic regulation. This study revealed a significant association between the abundance of specific oral bacteria and dyslipidemia, suggesting the potential of using the oral microbiota as a biomarker for the early detection and management of dyslipidemia. Future research should explore the mechanisms through which oral bacteria influence lipid metabolism and the potential for microbioma-based therapies. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Author(s): Takagi, Koki ; Tamura, Yoshihiro ; Narita, Norihiko ; Komatsu, Shotaro ; Yamazaki, Shunya ; Matsumura, Akihiro ; Kubota, Kosei ; Matsumiya, Tomoh ; Sawada, Kaori ; Nakaji, Shigeyuki ; Mikami, Tatsuya ; Kobayashi, Wataru | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
en : Folia Microbiologica 発行日 2025-04-02 |
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| 関連情報 | ||||||||||
| 言語 | en | |||||||||
| 関連名称 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12223-025-01258-4 | |||||||||
| 関連情報 | ||||||||||
| 言語 | en | |||||||||
| 関連名称 | Involvement of Megasphaera in the oral microbiome and dyslipidemia onset: evidence from a community-based study in Japan / Author: Koki Takagi et al Publication: Folia Microbiologica Publisher: Springer Nature Date: Apr 2, 2025 / Copyright © 2025, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i. | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 1874-9356 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1007/s12223-025-01258-4 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Springer | |||||||||
| 言語 | en | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 言語 | ja | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関名 | 弘前大学 | |||||||||
| 言語 | ja | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2025-09-30 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第2338号 | |||||||||
