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Association between oral bacterial species and halitosis: findings from a study of a community-based Japanese population
http://hdl.handle.net/10129/0002001872
http://hdl.handle.net/10129/0002001872e11758f5-1701-489c-8bbe-8d4e9643e133
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本文 (1.1 MB)
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内容要旨 (242 KB)
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審査要旨 (113 KB)
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| アイテムタイプ | リポジトリ登録用アイテムタイプ（シンプル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-11-25 | |||||||||
| タイトル | ||||||||||
| タイトル | Association between oral bacterial species and halitosis: findings from a study of a community-based Japanese population | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| その他のタイトル | ||||||||||
| その他のタイトル | 地域住民健診における口腔内細菌と口臭の関係 | |||||||||
| 言語 | ja | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | oral microbiome | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | halitosis | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | oral malodor | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | halitosis | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | population study | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | embargoed access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||
| 著者 |
小松, 正太朗
× 小松, 正太朗
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Halitosis is known to be associated with oral bacteria; however, its specific relationship with particular bacterial species within the oral microbiota remains uncertain. Our objective was to identify oral bacterial species associated with volatile sulfur compound (VSC) production that contribute to halitosis in a community-based Japanese population. This study included 1018 participants. Tongue plaque samples were collected and the oral microbiome was analyzed via 16S rDNA amplicon sequencing. Participants with VSC levels greater than 250 ppb were categorized as having oral malodor. Linear discriminant analysis effect size was used to compare bacterial compositions between participants with and without halitosis. In this study, we identified 37 bacterial genera in tongue plaque samples. Significant differences in bacterial composition were found between the malodor and control groups. Porphyromonas, Fusobacterium, and Solobacterium were more abundant in the malodor group, whereas Streptococcus and Rothia were more prevalent in the control group. Multiple regression analysis further revealed that Porphyromonas and Solobacterium abundances were positively correlated with oral malodor. We found that halitosis in this Japanese population is associated primarily with pathogenic periodontal bacteria (members of the red and orange complexes) and Solobacterium moorei. The bacterial community composition of individuals with halitosis differs significantly from that of healthy individuals, emphasizing the role of specific bacterial species in oral malodor development. These findings increase our understanding of the microbial basis of halitosis and suggest that targeting Solobacterium, along with treating periodontal disease, may be effective in combating halitosis. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Author(s): Komatsu, Shotaro ; Tamura, Yoshihiro ; Takagi, Koki ; Yamazaki, Shunya ; Matsumura, Akihiro ; Kubota, Kosei ; Narita, Norihiko ; Matsumiya, Tomoh ; Sawada, Kaori ; Mikami, Tatsuya ; Nakaji, Shigeyuki ; Kobayashi, Wataru | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
en : Journal of Breath Research 巻 19, 号 3, p. 036010, 発行日 2025-05-30 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 1752-7163 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1088/1752-7163/addc0c | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | This Accepted Manuscript is available for reuse under a CC BY-NC-ND licence after the 12 month embargo period provided that all the terms of the licence are adhered to” (unless there is a cover sheet applied to it by IOP which already states this). | |||||||||
| 言語 | en | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | This is the Accepted Manuscript version of an article accepted for publication in [Association between oral bacterial species and halitosis: findings from a study of a community-based Japanese population]. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at [10.1088/1752-7163/addc0c]. | |||||||||
| 言語 | en | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 出版者 | ||||||||||
| 出版者 | IOP | |||||||||
| 言語 | en | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 言語 | ja | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関名 | 弘前大学 | |||||||||
| 言語 | ja | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2025-09-30 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第2340号 | |||||||||
