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Improved Assessment of Juxtacortical Lesions in Multiple Sclerosis Using Highly-accelerated High-resolution Double Inversion Recovery MR Imaging with Deep Learning-based Reconstruction
http://hdl.handle.net/10129/0002001880
http://hdl.handle.net/10129/0002001880d64f2874-d718-4fdd-b288-b1afa511af6d
| 名前 / ファイル | ライセンス | アクション |
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本文 (2.8 MB)
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審査要旨 (257 KB)
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| Item type | リポジトリ登録用アイテムタイプ（シンプル）(1) | |||||||||
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| 公開日 | 2025-11-27 | |||||||||
| タイトル | ||||||||||
| タイトル | Improved Assessment of Juxtacortical Lesions in Multiple Sclerosis Using Highly-accelerated High-resolution Double Inversion Recovery MR Imaging with Deep Learning-based Reconstruction | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| その他のタイトル | ||||||||||
| その他のタイトル | 多発性硬化症患者の大脳皮質近傍病変におけるディープラーニング MR 画像再構成技術を用いた高速・高分解能 DIR 画像による診断精度の向上 | |||||||||
| 言語 | ja | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 著者 |
新宅, 智博
× 新宅, 智博
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Purpose: Recently, a novel deep learning (DL)-based technique for reconstructing highly undersampled MR data (DL-Speed, DLS) has been developed, which demonstrated superior performance over compressed sensing. This study aimed to achieve high-resolution double inversion recovery (DIR) imaging using DLS (DLS-DIR) and compare its diagnostic performance in the detection of juxtacortical multiple sclerosis (MS) lesions with that of conventional DIR (C-DIR). Methods: We retrospectively analyzed MRI data from 25 patients with MS who underwent a comprehensive imaging protocol, including 3D fluid-attenuated inversion recovery (FLAIR), C-DIR, and DLS-DIR. A voxel size of 1.3 × 1.3 × 1.4 mm3 with a scan duration of 3 mins 55s were used for C-DIR, and isotropic 0.7 mm voxels with a scan time of 4 mins 23s were employed for DLS-DIR. Two neuroradiologists assessed the juxtacortical MS lesions during 2 separate reading sessions (one with C-DIR and the other with DLS-DIR). Lesions were categorized as subcortical white matter lesions, intracortical lesions, or mixed lesions involving both subcortical white and gray matter. The lesion counts per region were compared between the imaging techniques using the Wilcoxon signed-rank test. Results: DLS-DIR detected a significantly higher number of juxtacortical MS lesions compared to C-DIR (Radiologist A: 211 lesions vs. 164 lesions; Radiologist B: 209 lesions vs. 157 lesions, P < 0.05). DLS-DIR also identified more intracortical lesions (Radiologist A: 22 additional lesions, Radiologist B: 34 additional lesions, P < 0.05) and more mixed lesions (Radiologist A: 46 additional lesions, Radiologist B: 42 additional lesions, P < 0.05). Conclusion: The DLS technology enables high-resolution, whole-brain DLS-DIR imaging within a 5 mins acquisition time, which can be seamlessly incorporated into routine clinical workflows. This approach substantially enhances the detection and evaluation of juxtacortical MS lesions. |
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| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Author(s): Shintaku, Tomohiro ; Ide, Satoru ; Nagaya, Haruka ; Ishimoto, Yuka ; Watanabe, Keita ; Oyu, Kazuhiko ; Kasai, Sera ; Umemura, Yoshihito ; Sasaki, Miho ; Saito, Kana ; Ozawa, Amo ; Nozaki, Atsushi ; Zhu, Xucheng ; Wakayama, Tetsuya ; Nishijima, Haruo ; Suzuki, Chieko ; Tomiyama, Masahiko ; Kakeda, Shingo | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
en : Magnetic Resonance in Medical Sciences 巻 24, 号 4, p. 論文ID: mp.2024-0126, 発行日 2025 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 1880-2206 | |||||||||
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| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 1347-3182 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.2463/mrms.mp.2024-0126 | |||||||||
| 権利情報 | ||||||||||
| 言語 | en | |||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. ©2025 Japanese Society for Magnetic Resonance in Medicine | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 日本磁気共鳴医学会 | |||||||||
| 言語 | ja | |||||||||
| 出版者 | ||||||||||
| 出版者 | Japanese Society for Magnetic Resonance in Medicine | |||||||||
| 言語 | en | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士（医学） | |||||||||
| 学位授与機関 | ||||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 弘前大学 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2025-09-30 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第2348号 | |||||||||
