| アイテムタイプ |
リポジトリ登録用アイテムタイプ（シンプル）(1) |
| 公開日 |
2025-12-15 |
| タイトル |
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|
タイトル |
RASL10A, a member of the RAS subfamily of small GTPases, suppresses the EMT and invasion of human lung adenocarcinoma A549 cells |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Nishizuka, Makoto
| en |
Nishizuka, Makoto
Faculty of Agriculture and Life Sciences, Hirosaki University
|
| ja |
弘前大学農学生命科学部
|
Search repository
Nakajima, Kanae
Odagiri, Chie
Wada, Nanaka
Sakai, Satoshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Lung adenocarcinoma (LUAD) is the most frequently diagnosed form of non-small cell lung cancer and is known to develop distant metastases, such as brain and bone metastases, which can considerably affect the prognosis of patients. Therefore, there is a need to elucidate the metastatic mechanisms of LUAD and establish treatments to control metastasis. In this study, Kaplan-Meier plotter analysis demonstrated that patients with LUAD and low RASL10A expression have a poor prognosis. Furthermore, loss or gain of function experiments revealed that RASL10A suppresses transforming growth factor-beta (TGF-β)-induced epithelial-mesenchymal transition (EMT) and the subsequent invasion of LUAD A549 cells. In addition, we found that RASL10A suppresses Smad3 phosphorylation and Snail expression during the early stages of EMT. These results indicate that RASL10A is a novel factor that inhibits TGF-β signaling-mediated EMT and invasion in A549 cells. RASL10A has the potential to become a new therapeutic target for patients with LUAD. |
|
言語 |
en |
| 書誌情報 |
en : Bioscience, Biotechnology, and Biochemistry（BBB）
巻 89,
号 7,
p. 945-953,
発行日 2025-04-08
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0916-8451 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1347-6947 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10824164 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1093/bbb/zbaf052 |
| 権利情報 |
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権利情報 |
Copyright © 2025, © The Author(s) 2025. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry. |
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言語 |
en |
| 権利情報 |
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|
権利情報 |
This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
言語 |
en |
Bioscience, Biotechnology, and Biochemistry(BBB)_2025_89(7)_945-953.pdf (1 MB)
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