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Functions and potential clinical applications of circular RNAs in hepatocellular carcinoma
http://hdl.handle.net/10129/0002001979
http://hdl.handle.net/10129/000200197904725f6e-e399-4752-9fb5-90dc8e07a9a2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Hepatoma Res. 2025;11:15 (5.9 MB)
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| アイテムタイプ | リポジトリ登録用アイテムタイプ（シンプル）(1) | |||||||||
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| 公開日 | 2026-03-12 | |||||||||
| タイトル | ||||||||||
| タイトル | Functions and potential clinical applications of circular RNAs in hepatocellular carcinoma | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 著者 |
Kuwamoto-Imanishi, Sachiko
× Kuwamoto-Imanishi, Sachiko
× Fujii, Hodaka
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| 著者所属 | ||||||||||
| 言語 | en | |||||||||
| 値 | Hirosaki University | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Hepatocellular carcinoma (HCC), which accounts for 75%-80% of primary liver cancers, is recognized worldwide as a highly lethal cancer. Adjunctive diagnostic biomarkers for HCC are α-fetoprotein (AFP), induced by the absence of vitamin K or its antagonist (PIVKA-II), and AFP-L3. Using multiple biomarkers, or biomarkers in combination with other clinical tests, is recommended from the perspective of sensitivity and specificity; however, this approach does not lend itself to early detection. Therefore, novel biomarkers are needed urgently. Non-coding RNAs, mainly circular RNAs (circRNAs), are key players in the progression and suppression of diseases, including cancer. Unlike linear RNAs, circRNAs are cyclic RNAs generated by 3’ to 5’ back-splicing. Advancements in RNA sequencing technology and bioinformatic pipelines mean that numerous circRNAs have been predicted and identified. These RNA molecules play a role in the progression/suppression of cancer through direct or indirect epigenetic regulation via microRNAs and proteins in cancer cells, as well as in the surrounding tumor microenvironment. Some circRNAs are tissue- or cell line-specific and are detected in exosomes, blood, and saliva. Importantly, circRNAs are more stable than linear cognate RNAs in vivo. This unique characteristic positions circRNAs as versatile materials with potential for use as biomarkers, in clinical tests, and as therapeutic applications. In the context of HCC, numerous circRNAs have been identified. Here, we describe the functions of circRNAs in HCC, the experimental methods in which they can be used, and their potential clinical applications. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Kuwamoto-Imanishi S, Fujii H. Functions and potential clinical applications of circular RNAs in hepatocellular carcinoma. Hepatoma Res. 2025;11:15. http://dx.doi.org/10.20517/2394-5079.2024.123 |
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| 言語 | en | |||||||||
| 書誌情報 |
en : Hepatoma Research 巻 11, p. 15, 発行日 2025 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 2394-5079 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2454-2520 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.20517/2394-5079.2024.123 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | © The Author(s) 2025. | |||||||||
| 言語 | en | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 出版者 | ||||||||||
| 出版者 | OAE Publishing | |||||||||
| 言語 | en | |||||||||
