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The utility of the histopathology of bone marrow and spleen macrophages in diagnosing the cause of death: A retrospective observational study of forensic autopsy cases
http://hdl.handle.net/10129/0002001988
http://hdl.handle.net/10129/0002001988ed498d24-ad54-4cde-b1ea-983b955cfb5c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Hirosaki Med J 76-1-4_48.pdf (2.0 MB)
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| アイテムタイプ | リポジトリ登録用アイテムタイプ（フル）(1) | |||||||||||||
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| 公開日 | 2026-03-25 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | The utility of the histopathology of bone marrow and spleen macrophages in diagnosing the cause of death: A retrospective observational study of forensic autopsy cases | |||||||||||||
| 言語 | en | |||||||||||||
| 作成者 |
Tsushima, Kou
× Tsushima, Kou
× Takahashi, Shirushi
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| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Our prior study demonstrated an association between bone-marrow macrophages' morphological changes and the cause of death listed in forensic autopsies. To solve some methodological limitations, we herein investigated the relationship between the cause of death and macrophages in the bone marrow and the spleen in autopsy cases （including judicial cases）. We gathered bone marrow and spleen specimens from 183 forensic autopsy cases and conducted hematoxylin-eosin, Berlin blue, and immunostaining using antibodies against CD163, CD61, and CD138. We measured the densities of swollen, hemophagocytic, and hemosiderin-laden macrophages in each specimen and examined the decedents' background data. Our analyses revealed a correlation between the bone marrow's and spleen's numbers of macrophages with morphological changes. Compared to the acute-death group, the group of deaths with a prolonged agonal period showed a hemophagocytic tendency in both bone marrow and spleen, an increased number of hemosiderin-laden macrophages in the bone marrow, and an increased number of swollen splenic macrophages. Swollen and hemophagocytic macrophages in both organs were increased in the group in which a return of spontaneous circulation had been observed. These data indicate that examining the morphological changes of macrophages in both the bone marrow and the spleen in forensic autopsy cases helps distinguish the cause of death. | |||||||||||||
| 言語 | en | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | 弘前大学大学院医学研究科 | |||||||||||||
| 言語 | ja | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Hirosaki University Graduate School of Medicine | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AN00211444 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 0439-1721 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 2434-4656 | |||||||||||||
| 書誌情報 |
ja : 弘前医学 en : Hirosaki Medical Journal 巻 76, 号 1-4, p. 48-62, 発行日 2026-03-10 |
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