| アイテムタイプ |
リポジトリ登録用アイテムタイプ（フル）(1) |
| 公開日 |
2026-03-25 |
| タイトル |
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|
タイトル |
Reciprocal regulatory mechanisms between the integrated stress response pathway and cyclin D1 in the mitochondrial stress response |
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言語 |
en |
| 作成者 |
Hirao, Wataru
| en |
Hirao, Wataru
|
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Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine，Department of Glycobiology, Hirosaki University Graduate School of Medicine
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Search repository
Mimura, Junsei
| en |
Mimura, Junsei
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Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine
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Search repository
Kasai, Shuya
| en |
Kasai, Shuya
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Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine
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Search repository
Itoh, Ken
| en |
Itoh, Ken
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Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine
|
Search repository
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Mitochondria are essential organelles that orchestrate a wide array of cellular processes, including energy production and apoptosis. Perturbations arising from both exogenous and endogenous stressors can compromise mitochondrial function, contributing to the pathogenesis of numerous human diseases and the aging process. Despite their critical roles, the regulatory mechanisms governing mitochondrial stress responses and their functional consequences remain poorly understood. In the present study, we demonstrate that oligomycin-induced mitochondrial stress elicits downregulation of cyclin D1 （cycD1） and cell cycle arrest through activation of the integrated stress response （ISR） pathway in HEK293 cells. Moreover, we show that knockdown of cycD1 potentiates ISR activity in HeLa cells. Collectively, these findings uncover a previously unrecognized reciprocal crosstalk between cycD1 and the ISR pathway in the context of mitochondrial stress response. |
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言語 |
en |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科 |
|
言語 |
ja |
| 出版者 |
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出版者 |
Hirosaki University Graduate School of Medicine |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN00211444 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0439-1721 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2434-4656 |
| 書誌情報 |
ja : 弘前医学
en : Hirosaki Medical Journal
巻 76,
号 1-4,
p. 94-105,
発行日 2026-03-10
|
Hirosaki Med J 76-1-4_94.pdf (1.8 MB)
