{"created":"2023-05-15T09:02:31.638011+00:00","id":3368,"links":{},"metadata":{"_buckets":{"deposit":"546db950-fad1-4faa-b33c-8a544865e360"},"_deposit":{"created_by":3,"id":"3368","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3368"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003368","sets":["557:558:559"]},"author_link":["9401","9369","9356","9849","9372","9371","9375","9377","9355","9352","9844","9374","9368","9850","9359","9378","9360","9804","9351","9370","9373"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Efects of Zonisamide and Carbamazepine on Ca²⁺and K⁺ Evoked Hippocampal Glutamate Releases"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"104","bibliographicPageStart":"97","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"てんかん治療研究振興財団研究年報"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗てんかん薬carbamazepine(CBZ),zonisamide(ZNS)の抗てんかん作用発現機序解明を目的に,In vivo microdialysis electrode biosensorを用いた細胞外glutamate(GLU)濃度のreal time monitoringによる,Ca²⁺およびK⁺依存性GLU遊離に対するCBZ,ZNS両剤の効果を比較検討した。細胞外GLU濃度は細胞外Ca²⁺濃度の変化(0~3.4mM)に影響されなかったが,細胞外K⁺濃度の増加(100mM)により,一過性初期増加,ついで多相性間歇的増加相が生じた。CBZ(100/`M)そしてZNS(1mM)潅流投与は,この一過性初期増加,多相性間歇的増加相を抑制した。特にCBZは多相性間歇的増加相の抑制効果がZNSよりも強く,逆にZNSは一過性初期増加抑制効果がCBZよりも強力であった。このK⁺依存性GLU遊離に対する,CBZ,ZNSの抑制効果がCBZ,ZNS両剤の抗てんかん作用発現機序に関与する可能性が示唆される。","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"てんかん治療研究振興財団研究年報. 9, 1997, p.97-104","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9401","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オカダ, モトヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"9844","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カワタ, ユウコ"}]},{"nameIdentifiers":[{"nameIdentifier":"9849","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キリュウ, 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