{"created":"2023-05-15T09:02:31.899863+00:00","id":3374,"links":{},"metadata":{"_buckets":{"deposit":"946dfeb0-bcca-44be-8575-3d8da1b1405f"},"_deposit":{"created_by":3,"id":"3374","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3374"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003374","sets":["557:558:559"]},"author_link":["9373","9432","9351","9433","9436","9427","9368","9423","9429","9359"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Studies on the pathogeneses underlying epilepsy using model animals bearing a genetic abnormality identified in human epilepsy"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-06","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"54","bibliographicPageStart":"49","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"てんかん治療研究振興財団研究年報"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"常染色体優性夜間前頭葉てんかん(ADNFLE)の日本人家系から同定されたニコチ\nン性アセチルコリン食容体のa.4サブユニット遺伝子に異常を持つ遺伝子組換えモデル動\n物ラット(S284LTg)の作出に成功した｡S284LTgはヒトAl)NFLEと同様に睡眠中に前\n頭葉を焦点とする自発けいれんを示し.その発作はヒトADNFLEに特徴的な発作に酷似し\nていた｡神経伝達物質と陣眠覚醒リズムの相関他を解析した結果.覚醒から陣眼への移行\nにより減少するグルタミン酸やアセチルコ.)ンの遊離変化はS284L-Tgで認められなかった\nが.GABA遊離は非組換え体との有意な差は認めなかったO前頭葉スライスパッチクランプ\n解析では.S284LTgはグルタミン酸系には形響せず.GABA系伝達機能への克進効果が欠\n如していた｡覚醒から睡眠への移行段階での相対的グルタミン酸伝達横能の尤進が.特徴\n的な睡眠F71発作の発現機序の一端をなすと考えられたo我々が作出したS284L-Tgは. ヒト\nADNFLEと相同する遺伝子変異を有し.酷似した表現型を示すことから.自発発作を有す\nる世界初のヒトてんかんモデルラットと考えられた｡","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"てんかん治療研究振興財団研究年報. 18, 2007, p.49-54","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9433","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hirose, Shinichi"}]},{"nameIdentifiers":[{"nameIdentifier":"9373","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Okada, Motohiro"}]},{"nameIdentifiers":[{"nameIdentifier":"9427","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Zhu, Gang"}]},{"nameIdentifiers":[{"nameIdentifier":"9436","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yoshida, Shukuko"}]},{"nameIdentifiers":[{"nameIdentifier":"9359","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kaneko, 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