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(3-en),4-en一VPA(4-en)の三つの不飽和代謝産\n物-の代謝に与える影響を検討した｡また上記の3因子および不飽和代謝産物の血清濃度と\n血菜アンモニア濃度の関係も検討した｡単剤群で4-en/VPA比は年齢と有意な負の相関,VPA\n濃度と有意な正の相関を示した011歳以上で多剤併用群は単剤群に比較し,4-en/VPA比は\n有意に高値を,2-en/VPA比は有意に低値を示した｡血菜アンモニア膿度は多剤併用群で早\n剤群より有意に高値を示した｡上記の3因子はVPAから最も肝毒性の強い4-en-の代謝を\n促進することにより肝障害を惹起し,多剤併用はβ酸化を抑制することにより高アンモニア\n血症を惹起する可能性が考えられた。","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"てんかん治療研究振興財団研究年報. 3, 1991, p.99-105","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9455","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオタニ, コウイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"9364","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コンドウ, ツヨシ"}]},{"nameIdentifiers":[{"nameIdentifier":"9355","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カネコ, 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