{"created":"2023-05-15T09:02:32.847810+00:00","id":3395,"links":{},"metadata":{"_buckets":{"deposit":"0eef2bff-e30d-465a-8fc4-60f8d17a69ff"},"_deposit":{"created_by":3,"id":"3395","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3395"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003395","sets":["557:558:559"]},"author_link":["9467","9365","9351","9464","9440","9601"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"516","bibliographicPageStart":"511","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Neurosciences : 日本脳研究会会誌"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify the mechanisms of antimanic effects of Zotepine (ZTP), the effects of ZTP on serotonin (5-HT), dopamine (DA), noradrenaline (NA), and gamma amino butyric acid (GABA) re-uptakes, and on glutamic acid decarboxylase (GAD) activity were investigated. ZTP blocked selectively 5-HT\nre-uptake in all rat brain regions examined, and its blockade effect was almost equal to 5- HT, while chlorpromazine (CP), haloperidol (HPD) and imipramine (iMI) showed no inhibition. ZTP of higher\nconcentration inhibited DA, NA and GABA reuptakes moderately. ZTP had no significant effect on GAD activity. ZTP had ignificantly higher inhibitory effect on 5- HT re-uptake than on other monoamines and GABA re-uptakes. These results suggest that the inhibition of 5- HT re-uptake by ZTP at least partly explains the anti-manic effect\nof the drug. ZTP may act pre-synaptically\nas well as post-synaptically, and 5-HT may have more important roles in the athogenesis of mania than other monoamines.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Neurosciences : 日本脳研究会会誌. 16, 1990, p.511-516","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本脳研究会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_rights_14":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは日本脳科学会の許諾に基づき複製したものである。"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10033568","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0388-7448","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.7","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Neuropsychiatry, School of Medicine, Hirosaki University"},{"subitem_text_value":"Department of Neuropsychiatry, School of Medicine, Hirosaki University"},{"subitem_text_value":"Department of Neuropsychiatry, School of Medicine, Hirosaki University"},{"subitem_text_value":"Department of Neuropsychiatry, School of Medicine, Hirosaki University"},{"subitem_text_value":"Department of Neuropsychiatry, School of Medicine, Hirosaki University"},{"subitem_text_value":"Department of Neuropsychiatry, School of Medicine, Hirosaki University"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirano, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"9467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaneko, Sunao"}],"nameIdentifiers":[{"nameIdentifier":"9351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Otani, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"9464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"9365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasa, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"9601","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushima, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"9440","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"Neurosciences_16_511.pdf","filesize":[{"value":"239.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Neurosciences_16_511.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3395/files/Neurosciences_16_511.pdf"},"version_id":"61a5488a-1346-4598-a76c-e74017a3ca8c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"zotepine","subitem_subject_scheme":"Other"},{"subitem_subject":"mania","subitem_subject_scheme":"Other"},{"subitem_subject":"serotonin","subitem_subject_scheme":"Other"},{"subitem_subject":"re-uptake","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mechanisms of Antimantic Effects of Zotepine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mechanisms of Antimantic Effects of Zotepine"}]},"item_type_id":"3","owner":"3","path":["559"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-06-26"},"publish_date":"2009-06-26","publish_status":"0","recid":"3395","relation_version_is_last":true,"title":["Mechanisms of Antimantic Effects of Zotepine"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:51:40.547269+00:00"}